Misoprostol and Zoloft drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Misoprostol (misoprostol) and Zoloft (sertraline hydrochloride). Common drug interactions include dizziness among females and dysphagia among males.
The phase IV clinical study analyzes what interactions people have when they take Misoprostol and Zoloft. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.
What is Misoprostol?
Misoprostol has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 8,222 Misoprostol users. Check the latest studies of Misoprostol.
What is Zoloft?
Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.
34 people who take Misoprostol and Zoloft together, and have interactions are studied.

What are the common drug interactions of Misoprostol and Zoloft, by gender? *:
female:
- Dizziness
- Dry mouth
- Fall
- Gait disturbance
- Intestinal mass
- Kidney infection
- Limb injury
- Mass
- Mitral valve incompetence (inefficient heart valve)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
male:
- Dysphagia (a condition in which swallowing is difficult or painful)
- Vomiting
- Oropharyngeal pain
- Pain in jaw
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Rash
- Throat tightness
- Tinnitus (a ringing in the ears)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Hypotension (abnormally low blood pressure)
What are the common drug interactions of Misoprostol and Zoloft, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Human chorionic gonadotropin increased
- Pregnancy test false positive
20-29:
- Adrenal disorder
- Anaemia (lack of blood)
- Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
- Blindness
- Blood glucose increased
- Bone marrow disorder
- Carotid artery occlusion (artery blockage)
- Constipation
- Deafness
- Diarrhoea
30-39:
- Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
- Blindness
- Body height decreased
- Drug ineffective
- Starvation (a severe deficiency in caloric energy, nutrient, and vitamin intake)
- Tardive dyskinesia (a disorder that involves involuntary movements)
- Weight decreased
- Agitation (state of anxiety or nervous excitement)
- Abortion spontaneous (naturally occurring miscarriage)
- Maternal exposure before pregnancy (use of substance before pregnancy)
40-49:
- Aortic dilatation
- Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
- Hypoxia (low oxygen in tissues)
- Psoriasis (immune-mediated disease that affects the skin)
- Pulmonary artery stenosis (narrowing (stenosis) that occurs in the lung artery)
- Transposition of the great vessels
- Deafness
- Dyspnoea exertional (breathlessness or shortness of breath)
- Muscle cramps (painful sensations caused by muscle contraction)
50-59:
- Hypertension (high blood pressure)
- Abnormal behaviour
- Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
- Drug ineffective
- Dyspnoea (difficult or laboured respiration)
- General physical health deterioration (weak health status)
- Injury
- Obesity (having too much body fat)
- Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
- Pregnancy with contraceptive device
60+:
- Vomiting
- Dysphagia (a condition in which swallowing is difficult or painful)
- Oropharyngeal pain
- Pain in jaw
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Rash
- Throat tightness
- Tinnitus (a ringing in the ears)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Hypotension (abnormally low blood pressure)
What are the existing conditions these people have? *
- Pain: 6 people, 17.65%
- High Blood Cholesterol: 6 people, 17.65%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.71%
- High Blood Pressure: 5 people, 14.71%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 14.71%
- Memory Loss: 4 people, 11.76%
- Drowsiness: 4 people, 11.76%
- Erosive Oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time): 4 people, 11.76%
- Fatigue (feeling of tiredness): 4 people, 11.76%
- Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 4 people, 11.76%
* Approximation only. Some reports may have incomplete information.
Do you take Misoprostol and Zoloft?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Misoprostol (8,222 reports)
- Zoloft (138,798 reports)
Browse all drug interactions of Misoprostol and Zoloft:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Misoprostol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zoloft:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Misoprostol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zoloft and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on misoprostol and sertraline hydrochloride (the active ingredients of Misoprostol and Zoloft, respectively), and Misoprostol and Zoloft (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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