Imodium and Delsym drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Delsym (dextromethorphan polistirex). Common drug interactions include skin exfoliation among females and blood magnesium decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Delsym. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Delsym?

Delsym has active ingredients of dextromethorphan polistirex. It is often used in cough. eHealthMe is studying from 5,033 Delsym users. Check the latest studies of Delsym.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

41 people who take Imodium and Delsym together, and have interactions are studied.

What are the common drug interactions of Imodium and Delsym, by gender? *:

female:

Skin exfoliation (removal of the oldest dead skin cells)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Upper respiratory tract infection
Urinary retention (the inability to completely or partially empty the bladder)
Vertigo
Weight increased
White blood cell count decreased
Abdominal pain lower
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

male:

Blood magnesium decreased
Dehydration (dryness resulting from the removal of water)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood calcium decreased
Blood creatinine increased
Blood glucose increased
Blood pressure increased
Blood urea decreased
Blood urea increased

What are the common drug interactions of Imodium and Delsym, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiomyopathy (weakening of the heart muscle)
Carotid bruit (sound heard over the carotid artery area during auscultation)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic nephropathy (diabetic kidney disease)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Hypoxia (low oxygen in tissues)

50-59:

Fatigue (feeling of tiredness)
Pneumonia
Back pain
Blood sodium decreased
Hot flush (sudden feelings of heat)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Neoplasm malignant (cancer tumour)
Night sweats (sweating in night)

60+:

Blood magnesium decreased
Dehydration (dryness resulting from the removal of water)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Anaemia (lack of blood)
Aortic atherosclerosis (degenerative process of aortic arteries)
Aortic dilatation
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Arthropathy

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 34.15%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 3 people, 7.32%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.32%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 7.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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