Profen and Tenex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Tenex (guanfacine hydrochloride). Common drug interactions include metamyelocyte count increased among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Tenex. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

29 people who take Profen and Tenex together, and have interactions are studied.

What are the common drug interactions of Profen and Tenex, by gender? *:

female:

Metamyelocyte count increased (excess precursor in the granulocytic series)
Mitral valve incompetence (inefficient heart valve)
Monocyte count decreased
Myalgia (muscle pain)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Neck pain
Neuralgia (pain in one or more nerves)
Oedema peripheral (superficial swelling)

male:

Agitation (state of anxiety or nervous excitement)
Pneumonia
Abdominal tenderness
Ileus (a painful obstruction of the ileum or other part of the intestine)
Accidental exposure
Blindness
Cough
Decreased appetite
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Profen and Tenex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal distension
Abdominal tenderness
Ileus (a painful obstruction of the ileum or other part of the intestine)
Accidental exposure

10-19:

Aggression
Agitation (state of anxiety or nervous excitement)
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Irritability
Mania (a state of abnormally elevated or irritable mood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

20-29:

Hallucination (an experience involving the perception of something not present)
Mood altered (changes in mood)
Myalgia (muscle pain)
Neuralgia (pain in one or more nerves)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Burning sensation

30-39:

n/a

40-49:

Drug ineffective
Cough
Decreased appetite
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Dystonia (abnormal muscle tone)
Ear pain
Fall
Headache (pain in head)
Hypersensitivity

50-59:

Renal impairment (severely reduced kidney function)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

60+:

Dizziness
Dyspnoea (difficult or laboured respiration)
Blindness
Blindness unilateral
Blood albumin decreased
Blood creatinine increased
Blood glucose increased
Blood magnesium decreased
Blood potassium increased
Blood sodium decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 20.69%
Pneumonia: 5 people, 17.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.79%
Depression: 3 people, 10.34%
High Blood Pressure: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Tenex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously