Imodium and Librium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Librium (chlordiazepoxide hydrochloride). Common drug interactions include pleurisy among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Librium. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

18 people who take Imodium and Librium together, and have interactions are studied.

What are the common drug interactions of Imodium and Librium, by gender? *:

female:

Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pulmonary embolism (blockage of the main artery of the lung)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Abdominal pain
Collapse of lung (functional breakdown of lung)
Fall
Abdominal pain upper
Asthenia (weakness)
Drug ineffective
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

male:

Abnormal behaviour
Blood pressure systolic increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)
Restlessness (not able to rest)

What are the common drug interactions of Imodium and Librium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)

30-39:

n/a

40-49:

Abdominal pain
Abdominal pain upper
Asthenia (weakness)
Back pain
Headache (pain in head)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Swelling face
Swollen tongue (swelling of tongue)

50-59:

Abnormal behaviour
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Blood pressure systolic increased
Chronic kidney disease
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pericarditis (inflammation of the pericardium)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)

60+:

Abdominal pain
Abdominal pain lower
Death
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Drug ineffective
Eye movement disorder
Eye swelling
Fall
Feeling cold

What are the existing conditions these people have? *

Pain: 3 people, 16.67%
High Blood Pressure: 2 people, 11.11%
Type 2 Diabetes: 1 person, 5.56%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 1 person, 5.56%
Constipation: 1 person, 5.56%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.56%
Cystitis Interstitial (unknown cause characterized by bladder pain): 1 person, 5.56%
Depression: 1 person, 5.56%
Drug Dependence: 1 person, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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