Imodium and Ozempic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Ozempic (semaglutide). Common drug interactions include dysphagia among females and ischaemic stroke among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Ozempic. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

53 people who take Imodium and Ozempic together, and have interactions are studied.

What are the common drug interactions of Imodium and Ozempic, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Faeces discoloured
Flatulence (flatus expelled through the anus)
Gait disturbance
Hepatomegaly (abnormal enlargement of the liver)
Hip arthroplasty
Hyperhidrosis (abnormally increased sweating)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypersensitivity

male:

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Prostate cancer
Muscle atrophy (a decrease in the mass of the muscle)
Pemphigoid (tense blisters on the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin ulcer
Thyroid disorder (thyroid diseases)
Abdominal pain upper
Anaemia (lack of blood)
Asthenia (weakness)

What are the common drug interactions of Imodium and Ozempic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Breast pain
Disease progression

50-59:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Pyrexia (fever)
Rectal polyp (fleshy growth occurring on the lining of the colon)
Renal impairment (severely reduced kidney function)
Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Stress
Vitamin b12 decreased
Abdominal distension

60+:

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Urinary tract infection
Spinal compression fracture (fracture due to spinal compression on bone)
Thyroid disorder (thyroid diseases)
Weight decreased
Abdominal distension
Abdominal pain
Blindness unilateral
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control

What are the existing conditions these people have? *

Type 2 Diabetes: 13 people, 24.53%
High Blood Pressure: 9 people, 16.98%
Hyperlipidaemia (presence of excess lipids in the blood): 9 people, 16.98%
Joint Pain: 9 people, 16.98%
Diabetes: 9 people, 16.98%
Pain: 9 people, 16.98%
Neuralgia (pain in one or more nerves): 8 people, 15.09%
Inflammatory Bowel Disease: 8 people, 15.09%
Oral Pain: 8 people, 15.09%
Renal Cell Carcinoma (a kidney cancer): 8 people, 15.09%

* Approximation only. Some reports may have incomplete information.

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