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Ritalin and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include weight increased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Adderall. It is created by eHealthMe based on reports of 2,387 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

2,387 people who take Ritalin and Adderall together, and have interactions are studied.

Ritalin and Adderall drug interactions.

What are the common drug interactions of Ritalin and Adderall, by gender? *

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What are the common drug interactions of Ritalin and Adderall, by age (0-1 to 60+)? *

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What are the existing conditions these people have? *

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* Approximation only. Some reports may have incomplete information.

Do you take Ritalin and Adderall?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ritalin and Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ritalin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adderall and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Ritalin and Adderall, respectively), and Ritalin and Adderall (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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