Lenalidomide and Restless leg syndrome - a phase IV clinical study of FDA data

Summary:

Restless leg syndrome is reported as a side effect among people who take Lenalidomide (lenalidomide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Restless leg syndrome when taking Lenalidomide. It is created by eHealthMe based on reports of 52,873 people who have side effects when taking Lenalidomide from the FDA, and is updated regularly.

What is Lenalidomide?

Lenalidomide has active ingredients of lenalidomide. eHealthMe is studying from 52,881 Lenalidomide users. Check the latest studies of Lenalidomide.

What is Restless leg syndrome?

Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 1,242 drugs and 1,936 conditions by eHealthMe. Check the latest studies of Restless leg syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

52,873 people reported to have side effects when taking Lenalidomide.
Among them, 16 people (0.03%) have Restless leg syndrome.

Could Lenalidomide cause Restless leg syndrome?

Among these 16 people:

How long have people been on Lenalidomide when they have Restless leg syndrome? *

What is the gender of people who have Restless leg syndrome when taking Lenalidomide? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Restless leg syndrome when taking Lenalidomide? *

What are other drugs people take besides Lenalidomide? *

Xarelto: 1 person, 6.25%
Vitamins: 1 person, 6.25%
Aspirin: 1 person, 6.25%
Carfilzomib: 1 person, 6.25%
Dexamethasone: 1 person, 6.25%
Dicyclomine Hydrochloride: 1 person, 6.25%
Digoxin: 1 person, 6.25%
Eliquis: 1 person, 6.25%
Estradiol: 1 person, 6.25%
Lasix: 1 person, 6.25%

What are other side effects people have besides Restless leg syndrome? *

Back Pain: 5 people, 31.25%
Fatigue (feeling of tiredness): 4 people, 25.00%
Nausea (feeling of having an urge to vomit): 4 people, 25.00%
Diarrhea: 3 people, 18.75%
Depression: 3 people, 18.75%
Neuropathy Peripheral (surface nerve damage): 2 people, 12.50%
Drowsiness: 2 people, 12.50%
Intervertebral Disc Compression (spinal disc compression): 2 people, 12.50%
Constipation: 2 people, 12.50%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 12.50%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 13 people, 81.25%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 6.25%
Burkitt Lymphoma (cancer of the lymphatic system): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Lenalidomide and have Restless leg syndrome?

- Check whether Restless leg syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lenalidomide:

Lenalidomide (52,881 reports)

Browse all side effects of Lenalidomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restless leg syndrome:

Restless leg syndrome (1,242 drugs)

Browse all the conditions that are associated with Restless leg syndrome:

Restless leg syndrome (1,936 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lenalidomide (the active ingredients of Lenalidomide) and Lenalidomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.