Imodium and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Pamelor (nortriptyline hydrochloride). Common drug interactions include hepatic steatosis among females and blood bilirubin increased among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Pamelor. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

On Jul, 12, 2026

38 people who take Imodium and Pamelor together, and have interactions are studied.

What are the common drug interactions of Imodium and Pamelor, by gender? *:

female:

Hepatic steatosis (fatty liver disease)
Hypokalaemia (low potassium)
Intervertebral disc protrusion (spinal disc protrusion)
Lymphadenopathy (disease or enlargement of lymph nodes)
Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Oropharyngeal pain
Osteoporosis (bones weak and more likely to break)
Pain
Pleural effusion (water on the lungs)

male:

Blood bilirubin increased
Blood carbon monoxide increased
Anxiety
Arthralgia (joint pain)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Fall

What are the common drug interactions of Imodium and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Proctalgia (pain in the rectum)
Abscess oral (abscess in the mouth)
Anaemia macrocytic (a macrocytic class of anaemia)
Anxiety
Aortic dilatation
Arteriovenous fistula
Arthralgia (joint pain)
Back disorder
Back pain
Blood albumin decreased

30-39:

Drug effect decreased
Weight increased

40-49:

Arthralgia (joint pain)
Blindness
Blood glucose decreased
Febrile neutropenia (fever with reduced white blood cells)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Rash erythematous (redness of the skin)
Renal failure (kidney dysfunction)

50-59:

Blood carbon monoxide increased
Haemoglobin decreased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Haemolytic anaemia (anaemia due to haemolysis)
Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Sulphaemoglobinaemia (excess sulfhemoglobin (sulfhb) in the blood)
Syncope (loss of consciousness with an inability to maintain postural tone)
Back pain

60+:

Anxiety
Cough
Osteoporosis (bones weak and more likely to break)
Pain
Pleural effusion (water on the lungs)
Renal failure (kidney dysfunction)
Anaemia macrocytic (a macrocytic class of anaemia)
Arteriovenous fistula
Back pain
Carotid artery stenosis (narrowing of carotid artery)

What are the existing conditions these people have? *

Pain: 11 people, 28.95%
Multiple Myeloma (cancer of the plasma cells): 7 people, 18.42%
Acute Kidney Failure: 6 people, 15.79%
Limb Discomfort (discomfort in leg): 6 people, 15.79%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Back Pain: 4 people, 10.53%
Depression: 3 people, 7.89%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 7.89%
Fever: 3 people, 7.89%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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