Imodium and Vivelle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Vivelle (estradiol). Common drug interactions include intestinal obstruction among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Vivelle. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

On Jul, 30, 2026

35 people who take Imodium and Vivelle together, and have interactions are studied.

What are the common drug interactions of Imodium and Vivelle, by gender? *:

female:

Intestinal obstruction
Speech disorder
Vision blurred
Abdominal discomfort
Arthralgia (joint pain)
Erythema (redness of the skin)
Hypersensitivity
Cataract (clouding of the lens inside the eye)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coma (state of unconsciousness lasting more than six hours)

male:

Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)
Central nervous system neoplasm (tumour of central nervous system)
Clavicle fracture
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Imodium and Vivelle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anal fissure
Dyspepsia (indigestion)

50-59:

Blood triglycerides increased
Bone density decreased
Breast cancer
Breast disorder
Breast mass
Breast pain
Bunion (a painful swelling on the first joint of the big toe)
Cataract (clouding of the lens inside the eye)
Coeliac disease (simple food intolerance)
Colitis (inflammation of colon)

60+:

Fatigue (feeling of tiredness)
Dehydration (dryness resulting from the removal of water)
Vomiting
Weight decreased
Anaemia (lack of blood)
Aortic calcification (aortic calcification sign of heart valve disease)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atrioventricular block first degree (heart block first degree)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood urea increased

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 12 people, 34.29%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 7 people, 20.00%
Prostate Cancer: 6 people, 17.14%
Abdominal Discomfort: 5 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 11.43%
Pain: 2 people, 5.71%
Hot Flush (sudden feelings of heat): 2 people, 5.71%
Hormone Level Abnormal: 2 people, 5.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.71%
Gait Disturbance: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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