Imuran and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imuran (azathioprine) and Accutane (isotretinoin). Common drug interactions include oedema peripheral among females and gastrointestinal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Imuran and Accutane. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Imuran?

Imuran has active ingredients of azathioprine. It is often used in crohn's disease. eHealthMe is studying from 34,915 Imuran users. Check the latest studies of Imuran.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Jul, 15, 2026

62 people who take Imuran and Accutane together, and have interactions are studied.

What are the common drug interactions of Imuran and Accutane, by gender? *:

female:

Oedema peripheral (superficial swelling)
Uterine cancer
Wound infection fungal
Dehydration (dryness resulting from the removal of water)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Weight increased
Abdominal pain
Abdominal pain upper
Insomnia (sleeplessness)
Migraine (headache)

male:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Post procedural complication
Swelling
Abdominal pain
Autoimmune hepatitis
Blood cholesterol increased
Burning sensation
Colitis (inflammation of colon)
Depression

What are the common drug interactions of Imuran and Accutane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Colitis (inflammation of colon)
Urinary tract infection
Depression
Anxiety
Autoimmune hepatitis
Inflammatory bowel disease
Irritable bowel syndrome
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

20-29:

Abdominal pain
Blood creatinine increased
Blood urea increased
Colitis (inflammation of colon)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Dyspepsia (indigestion)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Frequent bowel movements
Haematocrit decreased

30-39:

Anaemia (lack of blood)
Arthralgia (joint pain)
Depression
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatitis (inflammation of the liver)
Inflammatory bowel disease
Injury
Lip dry
Muscle spasms (muscle contraction)

40-49:

Anaemia (lack of blood)
Back pain
Conjunctivitis (pink eye)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Gastrointestinal injury (injury to gastrointestinal tract)
Headache (pain in head)
Inflammatory bowel disease
Neck pain
Sinusitis (inflammation of sinus)
Tonsillar disorder (disease of tonsil)

50-59:

Headache (pain in head)
Alanine aminotransferase increased
Blood creatinine decreased
Blood lactate dehydrogenase increased
Blood triglycerides increased
Blood urea decreased
Brain stem syndrome
Csf cell count increased
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Depressed level of consciousness

60+:

n/a

What are the existing conditions these people have? *

Autoimmune Hepatitis: 19 people, 30.65%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 9.68%
Asthma: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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