Imuran and Multihance drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Imuran (azathioprine) and Multihance (gadobenate dimeglumine). Common drug interactions include nephrogenic systemic fibrosis among females and general physical health deterioration among males.
The phase IV clinical study analyzes what interactions people have when they take Imuran and Multihance. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.
What is Imuran?
Imuran has active ingredients of azathioprine. It is often used in crohn's disease. eHealthMe is studying from 34,915 Imuran users. Check the latest studies of Imuran.
What is Multihance?
Multihance has active ingredients of gadobenate dimeglumine. eHealthMe is studying from 5,786 Multihance users. Check the latest studies of Multihance.
20 people who take Imuran and Multihance together, and have interactions are studied.

What are the common drug interactions of Imuran and Multihance, by gender? *:
female:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Asthenia (weakness)
- Mobility decreased (ability to move is reduced)
- Pain
- Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Emotional distress
- Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
- Gait disturbance
male:
- General physical health deterioration (weak health status)
- Joint range of motion decreased (disease of joint movement)
- Joint stiffness
- Mobility decreased (ability to move is reduced)
- Muscle contractions involuntary (uncontrolled muscle contraction)
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Oedema peripheral (superficial swelling)
- Skin discolouration (change of skin colour)
- Skin fibrosis (fibrous tissue formation on skin)
- Skin hyperpigmentation (disorders affect the colour of your skin)
What are the common drug interactions of Imuran and Multihance, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Asthenia (weakness)
- Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
- Gait disturbance
- Hypoaesthesia (reduced sense of touch or sensation)
- Joint range of motion decreased (disease of joint movement)
- Joint stiffness
- Mobility decreased (ability to move is reduced)
- Muscle tightness
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
30-39:
n/a
40-49:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Dry skin
- Emotional distress
- General physical health deterioration (weak health status)
- Joint contracture (a permanent shortening of a muscle or joint)
- Joint range of motion decreased (disease of joint movement)
- Neuropathic arthropathy (a progressive destruction of bone and joints)
- Oedema (fluid collection in tissue)
50-59:
- Arthralgia (joint pain)
- Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
- Gait disturbance
- General physical health deterioration (weak health status)
- Joint range of motion decreased (disease of joint movement)
- Joint stiffness
- Mobility decreased (ability to move is reduced)
- Muscle contractions involuntary (uncontrolled muscle contraction)
- Muscular weakness (muscle weakness)
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
60+:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Pain
- Pain of skin
- Peau d'orange (orange peel skin)
- Pruritus (severe itching of the skin)
- Scar
- Skin hypertrophy (skin cells enlarges)
- Skin lesion
- Skin tightness
What are the existing conditions these people have? *
- Nuclear Magnetic Resonance Imaging Abdominal: 8 people, 40.00%
- Nuclear Magnetic Resonance Imaging Brain: 4 people, 20.00%
- Renal Vein Thrombosis (blood clot in renal vein): 1 person, 5.00%
- Ovarian Mass (mass in ovary): 1 person, 5.00%
- Hepatic Vein Obstruction (Budd-Chiari) (blockage of the hepatic vein): 1 person, 5.00%
- Colon Cancer Metastatic (cancer of colon spreads to other part of body): 1 person, 5.00%
- Abdominal Pain: 1 person, 5.00%
* Approximation only. Some reports may have incomplete information.
Do you take Imuran and Multihance?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Imuran (34,915 reports)
- Multihance (5,786 reports)
Browse all drug interactions of Imuran and Multihance:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Imuran:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Multihance:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Imuran and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Multihance and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Almarshad HA, "Effect of ginger rhizome extract on lymphocytopenic guinea pig with azathioprine", African Journal of Pharmacy and Pharmacology, 2014 Nov .
- Almarshad HA, "Effect of ginger rhizome extract on lymphocytopenic guinea pig with azathioprine", African Journal of Pharmacy and Pharmacology, 2014 Nov .
How the study uses the data?
The study uses data from the FDA. It is based on azathioprine and gadobenate dimeglumine (the active ingredients of Imuran and Multihance, respectively), and Imuran and Multihance (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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