Incivek and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Incivek (telaprevir) and Methotrexate (methotrexate sodium). Common drug interactions include headache among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Incivek and Methotrexate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Incivek?

Incivek has active ingredients of telaprevir. It is often used in hepatitis c. eHealthMe is studying from 15,526 Incivek users. Check the latest studies of Incivek.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 11, 2026

16 people who take Incivek and Methotrexate together, and have interactions are studied.

Incivek and Methotrexate drug interactions.

What are the common drug interactions of Incivek and Methotrexate, by gender? *:

female:

Headache (pain in head)
Herpes zoster
Hot flush (sudden feelings of heat)
Human herpesvirus 6 infection
Hyperglycaemia (high blood sugar)
Influenza like illness
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Oesophagitis (inflammation of oesophagus)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Weight decreased
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anal pruritus (anal itching)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
B-cell lymphoma (blood cancer affecting b cells)
Cardiac failure

What are the common drug interactions of Incivek and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Influenza like illness
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Oesophagitis (inflammation of oesophagus)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

Anal ulcer
Depression
Neuritis (inflammation of nerve)
Weight decreased
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Anal pruritus (anal itching)
Anorectal discomfort
Arthralgia (joint pain)
B-cell lymphoma (blood cancer affecting b cells)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Diarrhoea
Hypokalaemia (low potassium)
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Coccidioidomycosis (serious disease of the lungs and other tissues, caused by the fungus coccidioides immitis)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Herpes zoster

60+:

Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Cytomegalovirus test positive
Dyspnoea (difficult or laboured respiration)
Excoriation (to tear or wear off the skin of)
Facial bones fracture (bone fracture of face)
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Groin pain
Herpes virus infection

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 18.75%
Pain: 3 people, 18.75%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 12.50%
Bone Marrow Conditioning Regimen: 2 people, 12.50%
Headache (pain in head): 2 people, 12.50%
Uveitis (inflammation of the uvea): 1 person, 6.25%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 6.25%
B Precursor Type Acute Leukaemia (lymphoid cancer): 1 person, 6.25%
Bone Sarcoma (bone cancer): 1 person, 6.25%
Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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