Indapamide and Xyrem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Indapamide (indapamide) and Xyrem (sodium oxybate). Common drug interactions include respiratory depression among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Indapamide and Xyrem. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Indapamide?

Indapamide has active ingredients of indapamide. It is often used in high blood pressure. eHealthMe is studying from 22,153 Indapamide users. Check the latest studies of Indapamide.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

65 people who take Indapamide and Xyrem together, and have interactions are studied.

What are the common drug interactions of Indapamide and Xyrem, by gender? *:

female:

Respiratory depression (respiration has a rate below 12 breaths)
Rosacea (a skin condition that causes facial redness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Wound
Back pain
Blood potassium decreased
Depression
Dizziness
Drug dependence

male:

Cardiac failure congestive
Chronic kidney disease
Gout (uric acid crystals building up in the body)
Hypersensitivity
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Indapamide and Xyrem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Depression
Heart rate increased
Homicidal ideation (thoughts about human killing another human)
Loss of consciousness
Panic attack
Suicidal ideation
Aggression
Anger
Anxiety

30-39:

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Streptococcal infection
Tonsillitis (inflammation of tonsil)
Hyperhidrosis (abnormally increased sweating)
Oedema (fluid collection in tissue)

40-49:

Back pain
Facial bones fracture (bone fracture of face)
Fall
Food allergy
Lacrimation increased
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Streptococcal infection
Tonsillitis (inflammation of tonsil)

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Anxiety
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Depressed level of consciousness
Diarrhoea
Euphoric mood (excessively happy but may become angry or irritable)
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

60+:

Fall
Cardiac failure congestive
Constipation
Death
Fatigue (feeling of tiredness)
Fracture
Hip fracture
Incontinence (lack of moderation or self-control)
Intestinal obstruction
Lung neoplasm malignant (cancer tumour of lung)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 33 people, 50.77%
Drowsiness: 7 people, 10.77%

* Approximation only. Some reports may have incomplete information.

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