Indocin and Ditropan drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Indocin (indomethacin) and Ditropan (oxybutynin chloride). Common drug interactions include depression among females and blood bilirubin increased among males.
The phase IV clinical study analyzes what interactions people have when they take Indocin and Ditropan. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.
What is Indocin?
Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.
What is Ditropan?
Ditropan has active ingredients of oxybutynin chloride. It is often used in urge incontinence. eHealthMe is studying from 11,799 Ditropan users. Check the latest studies of Ditropan.
20 people who take Indocin and Ditropan together, and have interactions are studied.

What are the common drug interactions of Indocin and Ditropan, by gender? *:
female:
- Depression
- Back pain
- Body temperature increased
- Completed suicide (act of taking one's own life)
- Ear discomfort
- Ear pain
- Overdose
- Pruritus (severe itching of the skin)
- Suicidal ideation
- Urticaria (rash of round, red welts on the skin that itch intensely)
male:
- Blood bilirubin increased
- Staphylococcal infection (an infection with staphylococcus bacteria)
- Peripheral swelling
- Aspartate aminotransferase increased
- Blood creatinine increased
- Fall
- Haematocrit decreased
- Haemoglobin decreased
- Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
- Hepatic function abnormal
What are the common drug interactions of Indocin and Ditropan, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Back pain
- Body temperature increased
- Completed suicide (act of taking one's own life)
- Depression
- Ear discomfort
- Ear pain
- Overdose
- Pruritus (severe itching of the skin)
- Suicidal ideation
- Urticaria (rash of round, red welts on the skin that itch intensely)
50-59:
- Arthralgia (joint pain)
- Dysstasia (difficulty in standing)
- Erythema (redness of the skin)
- Foot fracture
- Joint swelling
- Localised infection (infection at the single location)
- Pain in extremity
- Peripheral swelling
- Colon cancer recurrent
60+:
- Blood bilirubin increased
- Staphylococcal infection (an infection with staphylococcus bacteria)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Fall
- Multiple fractures
- Acetabulum fracture (socket of the hip joint- fracture)
- Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
- Aspartate aminotransferase increased
- Blood creatinine increased
- Bone disorder
What are the existing conditions these people have? *
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 25.00%
- Pain: 4 people, 20.00%
- Stress And Anxiety: 3 people, 15.00%
- Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 15.00%
- Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 3 people, 15.00%
- Migraine (headache): 3 people, 15.00%
- Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.00%
- Sleep Disorder: 1 person, 5.00%
- Progressive Relapsing Multiple Sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both): 1 person, 5.00%
- Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 5.00%
* Approximation only. Some reports may have incomplete information.
Do you take Indocin and Ditropan?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Indocin and Ditropan:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Indocin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Ditropan:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Indocin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Ditropan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
- Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
How the study uses the data?
The study uses data from the FDA. It is based on indomethacin and oxybutynin chloride (the active ingredients of Indocin and Ditropan, respectively), and Indocin and Ditropan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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