Intelence and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Intelence (etravirine) and Zide (hydrochlorothiazide). Common drug interactions include vertigo among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Intelence and Zide. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Intelence?

Intelence has active ingredients of etravirine. It is often used in hiv infection. eHealthMe is studying from 3,797 Intelence users. Check the latest studies of Intelence.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

81 people who take Intelence and Zide together, and have interactions are studied.

What are the common drug interactions of Intelence and Zide, by gender? *:

female:

Vertigo
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Death
Depression
Escherichia infection (bacterial infection by escherichia coli)
Face oedema (swelling of face)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Blood albumin decreased

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Blood creatinine increased
Mobility decreased (ability to move is reduced)
Renal impairment (severely reduced kidney function)
Gait disturbance
Hand fracture

What are the common drug interactions of Intelence and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Device expulsion
Hip deformity
Hiv test positive
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Tendonitis (a condition that causes pain and swelling of tendons)

30-39:

Renal failure (kidney dysfunction)
Anxiety
Chronic kidney disease
Depression
Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteopenia (a condition where bone mineral density is lower than normal)
Chronic kidney disease
Bone density decreased
Hip arthroplasty
Blood creatinine increased
Osteoporosis (bones weak and more likely to break)

50-59:

Postoperative wound infection
Pruritus generalised (generalized itching)
Pyrexia (fever)
Rash
Rectal haemorrhage (bleeding from anus)
Renal tubular necrosis (death of kidney tubules)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Skin exfoliation (removal of the oldest dead skin cells)
Spinal compression fracture (fracture due to spinal compression on bone)

60+:

Renal failure (kidney dysfunction)
Blood triglycerides increased
Blood glucose increased
Blood pressure systolic increased
Chronic kidney disease
Cushingoid (obesity and weakening of the muscles)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Emotional distress
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Hiv Infection: 72 people, 88.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.64%
Pain: 6 people, 7.41%
Depression: 6 people, 7.41%
Dyspnea (difficult or laboured breathing): 5 people, 6.17%
Asthma: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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