Isoniazid and Augmentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isoniazid (isoniazid) and Augmentin (amoxicillin; clavulanate potassium). Common drug interactions include abdominal pain among females and meningitis among males.

The phase IV clinical study analyzes what interactions people have when they take Isoniazid and Augmentin. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Isoniazid?

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. eHealthMe is studying from 20,174 Isoniazid users. Check the latest studies of Isoniazid.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

On Jul, 23, 2026

68 people who take Isoniazid and Augmentin together, and have interactions are studied.

Isoniazid and Augmentin drug interactions.

What are the common drug interactions of Isoniazid and Augmentin, by gender? *:

female:

Abdominal pain
Death
Pain in extremity
Abdominal discomfort
Abdominal pain upper
Anaemia (lack of blood)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Renal impairment (severely reduced kidney function)
Blood magnesium decreased
Blood sodium increased
Blood thyroid stimulating hormone increased
C-reactive protein increased
Haematocrit
Haemoglobin decreased
Platelet count increased
Red blood cell count decreased

What are the common drug interactions of Isoniazid and Augmentin, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Bacteriuria (presence of bacteria in urine)
Decreased activity
Dehydration (dryness resulting from the removal of water)
Electrolyte imbalance
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Irritability
Kidney enlargement
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

2-9:

n/a

10-19:

Acute hepatic failure
Disease progression
Drug resistance (reduction in effectiveness of a drug)
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured

30-39:

Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Renal impairment (severely reduced kidney function)
Blood albumin decreased
Blood calcium decreased
Blood magnesium decreased
Blood potassium decreased
Blood sodium increased
Blood thyroid stimulating hormone increased
Blood urea increased
C-reactive protein increased

40-49:

Anaemia (lack of blood)
Death
Extrapulmonary tuberculosis (tb which occurs in any other part of the body outside the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abortion spontaneous (naturally occurring miscarriage)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fibrin d dimer increased
Hypercoagulation (increased tendency for clotting of the blood)

50-59:

Mass
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pulmonary mass
Swelling
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Wound
Alanine aminotransferase increased
Blood albumin decreased

60+:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Alanine aminotransferase increased
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diastolic dysfunction
Hepatitis (inflammation of the liver)
Pleural fibrosis (formation of fibrous tissue in lung)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the existing conditions these people have? *

Hiv Infection: 12 people, 17.65%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 13.24%
Pneumonia: 8 people, 11.76%
Pulmonary Tuberculosis (lungs tuberculosis): 6 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.88%
Fever: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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