Isoniazid and Pyrazinamide drug interactions - from FDA reports


Drug interactions are reported among people who take Isoniazid and Pyrazinamide together. This review analyzes the effectiveness and drug interactions between Isoniazid and Pyrazinamide. It is created by eHealthMe based on reports of 3,276 people who take the same drugs from FDA , and is updated regularly.



On Jun, 14, 2018

3,276 people who take Isoniazid, Pyrazinamide are studied.


Number of reports submitted per year:

Isoniazid and Pyrazinamide drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Pyrexia (fever)
  2. Renal failure acute (rapid kidney dysfunction)
  3. Acute generalised exanthematous pustulosis (acute febrile drug eruption)
  4. Aspartate aminotransferase increased
  5. Drug eruption (adverse drug reaction of the skin)
1 - 6 months:
  1. Pyrexia (fever)
  2. Alanine aminotransferase increased
  3. Anaemia (lack of blood)
  4. Aspartate aminotransferase increased
  5. Neutropenia (an abnormally low number of neutrophils)
6 - 12 months:
  1. Platelet count decreased
  2. Pneumonia
  3. Pneumonia bacterial (pneumonia associated with bacterial infection)
  4. Renal failure (kidney dysfunction)
  5. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
1 - 2 years:
  1. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  2. Concomitant disease progression (progress in accompanying disease)
  3. Disseminated tuberculosis
  4. Drug eruption (adverse drug reaction of the skin)
  5. Facial paralysis (loss of function of face muscle)
10+ years:
  1. Drug resistance (reduction in effectiveness of a drug)
not specified:
  1. Pyrexia (fever)
  2. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  3. Paradoxical drug reaction
  4. Vomiting
  5. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)

Most common drug interactions by gender *:

female:
  1. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  2. Hepatitis (inflammation of the liver)
  3. Hepatotoxicity (chemical-driven liver damage)
  4. Lymphadenopathy (disease or enlargement of lymph nodes)
  5. Paradoxical drug reaction
male:
  1. Pyrexia (fever)
  2. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  3. Alanine aminotransferase increased
  4. Anaemia (lack of blood)
  5. Hepatic failure (liver failure)

Most common drug interactions by age *:

0-1:
  1. Immune reconstitution syndrome (immune recovery syndrome)
  2. Acute hepatic failure
  3. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  4. Paradoxical drug reaction
  5. Hepatic failure (liver failure)
2-9:
  1. Paradoxical drug reaction
  2. Drug resistance (reduction in effectiveness of a drug)
  3. Pyrexia (fever)
  4. Hydrocephalus (water on the brain)
  5. Alanine aminotransferase increased
10-19:
  1. Pyrexia (fever)
  2. Dyspnoea (difficult or laboured respiration)
  3. Paradoxical drug reaction
  4. Acute hepatic failure
  5. Vomiting
30-39:
  1. Pyrexia (fever)
  2. Immune reconstitution syndrome (immune recovery syndrome)
  3. Lymphadenopathy (disease or enlargement of lymph nodes)
  4. Hepatitis (inflammation of the liver)
  5. Alanine aminotransferase increased
40-49:
  1. Pyrexia (fever)
  2. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  3. Vomiting
  4. Nausea (feeling of having an urge to vomit)
  5. Paradoxical drug reaction
50-59:
  1. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  2. Pyrexia (fever)
  3. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  4. Drug eruption (adverse drug reaction of the skin)
  5. Renal failure acute (rapid kidney dysfunction)
60+:
  1. Nausea (feeling of having an urge to vomit)
  2. Paradoxical drug reaction
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Pneumonia
  5. Hepatic function abnormal

* Approximation only. Some reports may have incomplete information.

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Related studies

Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 11,053 users)

Pyrazinamide

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. (latest outcomes from Pyrazinamide 4,343 users)


Interactions between Isoniazid and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Pyrazinamide and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Isoniazid and Pyrazinamide
a b c d e f g h i j k l m n o p q r s t u v w x y z

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Predict new side effects and undetected conditions when you take Isoniazid and Pyrazinamide (2,242 reports studied)

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