Isoptin and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isoptin (verapamil hydrochloride) and Amaryl (glimepiride). Common drug interactions include multi-organ failure among females and lactic acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Isoptin and Amaryl. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Isoptin?

Isoptin has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 5,539 Isoptin users. Check the latest studies of Isoptin.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Aug, 12, 2026

57 people who take Isoptin and Amaryl together, and have interactions are studied.

What are the common drug interactions of Isoptin and Amaryl, by gender? *:

female:

Multi-organ failure (multisystem organ failure)
Presyncope
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Vomiting
Areflexia (absence of a reflex)
Blood glucose decreased
Blood glucose increased
Coma (state of unconsciousness lasting more than six hours)
Death sudden
Depressed level of consciousness

male:

Lactic acidosis (low ph in body tissues)
Multi-organ failure (multisystem organ failure)
Bradycardia (abnormally slow heart action)
Concomitant disease progression (progress in accompanying disease)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Eczema weeping (an inflammatory form of skin disease marked by a fluid exudates)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Erythema (redness of the skin)
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the common drug interactions of Isoptin and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bone disorder
Burnout syndrome (problems related to life-management difficulty, but not considered a ""disorder)
Cardiovascular disorder (heart diseases)
Cataract (clouding of the lens inside the eye)
Depression
Femur fracture
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Influenza like illness
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)

20-29:

n/a

30-39:

n/a

40-49:

Angioedema (rapid swelling of the dermis)

50-59:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalitis (inflammation of the brain)
Restlessness (not able to rest)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Stupor (lack of critical cognitive function and level of consciousness)
Transitional cell carcinoma (cancer tumour inner most layer of urinary system)

60+:

Lactic acidosis (low ph in body tissues)
Multi-organ failure (multisystem organ failure)
Anaemia (lack of blood)
Balance disorder
Blood glucose increased
Bradycardia (abnormally slow heart action)
Concomitant disease progression (progress in accompanying disease)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Eczema weeping (an inflammatory form of skin disease marked by a fluid exudates)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 17.54%
Type 2 Diabetes: 7 people, 12.28%
Breast Cancer: 4 people, 7.02%
Pain: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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