Isordil and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isordil (isosorbide dinitrate) and Morphine (morphine sulfate). Common drug interactions include cardiac tamponade among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Isordil and Morphine. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

On Aug, 09, 2026

82 people who take Isordil and Morphine together, and have interactions are studied.

What are the common drug interactions of Isordil and Morphine, by gender? *:

female:

Cardiac tamponade (fluid accumulates in heart covering)
Electrocardiogram st segment depression
Hemiparesis (weakness on one side of the body)
Hypotension (abnormally low blood pressure)
Mitral valve incompetence (inefficient heart valve)
Pain in limb
Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
Ventricular fibrillation (abnormally irregular heart rhythm)
Abdominal pain
Anxiety

male:

Renal failure (kidney dysfunction)
Death
Stress
Chest pain
Hypotension (abnormally low blood pressure)
Cardiac arrest
Thrombosis (formation of a blood clot inside a blood vessel)
Pulmonary oedema (fluid accumulation in the lungs)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain upper

What are the common drug interactions of Isordil and Morphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

Chest pain
Peripheral ischaemia (impaired circulation to an extremity)
Abdominal pain upper
Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrioventricular block second degree (heart block second degree)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood potassium increased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiac tamponade (fluid accumulates in heart covering)

50-59:

Injury
Multi-organ failure (multisystem organ failure)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Renal impairment (severely reduced kidney function)
Stress
Abdominal pain
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cough
Nausea (feeling of having an urge to vomit)

60+:

Death
Renal failure (kidney dysfunction)
Multi-organ failure (multisystem organ failure)
Bradycardia (abnormally slow heart action)
Thrombocytopenia (decrease of platelets in blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Acute respiratory distress syndrome
Acute respiratory failure

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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