Isosorbide dinitrate and Bumex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide dinitrate (isosorbide dinitrate) and Bumex (bumetanide). Common drug interactions include headache among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide dinitrate and Bumex. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Bumex?

Bumex has active ingredients of bumetanide. It is often used in swelling. eHealthMe is studying from 9,210 Bumex users. Check the latest studies of Bumex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

48 people who take Isosorbide dinitrate and Bumex together, and have interactions are studied.

Isosorbide dinitrate and Bumex drug interactions.

What are the common drug interactions of Isosorbide Dinitrate and Bumex, by gender? *:

female:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Vomiting
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Fall
Multiple injuries
Neuropathy peripheral (surface nerve damage)
Cardiac disorder

male:

Cardiac failure congestive
Cardiac arrest
Renal failure chronic (long lasting kidney dysfunction)
Rib fracture
Subendocardial ischaemia
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Upper limb fracture
Dizziness
Drug ineffective

What are the common drug interactions of Isosorbide Dinitrate and Bumex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pancreatitis (inflammation of pancreas)
Papillary thyroid cancer
Post procedural hypothyroidism
Toxic nodular goitre (a thyroid gland that contains autonomously functioning thyroid nodules, with resulting excess thyroid hormone secretion)

40-49:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Duodenitis (inflammation of the duodenum)
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Confusional state

What are the existing conditions these people have? *

Coronary Heart Disease (narrowing or blockage of the coronary arteries): 5 people, 10.42%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 8.33%
Cardiac Disorder: 4 people, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 8.33%
High Blood Cholesterol: 3 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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