Isosorbide mononitrate and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Desyrel (trazodone hydrochloride). Common drug interactions include blood potassium decreased among females and sleep apnoea syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Desyrel. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

On Jul, 11, 2026

14 people who take Isosorbide mononitrate and Desyrel together, and have interactions are studied.

Isosorbide mononitrate and Desyrel drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Desyrel, by gender? *:

female:

Blood potassium decreased
Chest pain
Dizziness
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Injection site extravasation (flow of (blood or lymph) from injection site)
Ligament sprain (ligament stretched)
Localised infection (infection at the single location)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Malaise (a feeling of general discomfort or uneasiness)

male:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Cardiomyopathy (weakening of the heart muscle)
Abdominal hernia
Acute respiratory failure
Aortic arteriosclerosis (hardening of the aortic arteries)
Areflexia (absence of a reflex)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)

What are the common drug interactions of Isosorbide Mononitrate and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory failure
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Acute myocardial infarction (acute heart attack)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Hypoaesthesia (reduced sense of touch or sensation)
Pruritus (severe itching of the skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Throat tightness
Anaemia (lack of blood)
Blood iron decreased
Chest pain
Diarrhoea
Nausea (feeling of having an urge to vomit)

60+:

Chronic kidney disease
Fall
Diarrhoea
Dizziness
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Head injury
Headache (pain in head)
Hip fracture
Hypotension (abnormally low blood pressure)
Injection site extravasation (flow of (blood or lymph) from injection site)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
Pain: 4 people, 28.57%
High Blood Pressure: 3 people, 21.43%
Arterial Disorder: 2 people, 14.29%
Infection: 2 people, 14.29%
Depression: 1 person, 7.14%
Gastric Ulcer (stomach ulcer): 1 person, 7.14%
Gastric Disorder (disease of stomach): 1 person, 7.14%
Dyslipidaemia (abnormal amount of lipids): 1 person, 7.14%
Cardiac Failure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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