Isosorbide mononitrate and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Restoril (temazepam). Common drug interactions include arthralgia among females and encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Restoril. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

On Jul, 12, 2026

42 people who take Isosorbide mononitrate and Restoril together, and have interactions are studied.

Isosorbide mononitrate and Restoril drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Restoril, by gender? *:

female:

Arthralgia (joint pain)
Asthenia (weakness)
Balance disorder
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood glucose increased
Bone disorder
Cardiac disorder
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Comminuted fracture (bone has broken into several pieces)

male:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal failure acute (rapid kidney dysfunction)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Liver disorder (liver diseases)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)
Septic shock (shock due to blood infection)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Isosorbide Mononitrate and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Chronic kidney disease
Abdominal pain upper
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbuncle (a carbuncle is an abscess larger than a boil)
Cardiac failure congestive
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Septic shock (shock due to blood infection)
Staphylococcal bacteraemia (a bacterial infection of blood)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pneumonia
Serratia bacteraemia (bacterial blood infection)
Thrombocytopenia (decrease of platelets in blood)
Thrombosis (formation of a blood clot inside a blood vessel)
Aortic thrombosis (formation of a blood clot inside aorta)
Hypersensitivity

60+:

Nausea (feeling of having an urge to vomit)
Blindness
International normalised ratio increased
Malaise (a feeling of general discomfort or uneasiness)
Pancreatitis (inflammation of pancreas)
Renal failure acute (rapid kidney dysfunction)
Retinal artery occlusion (blockage of retinal artery)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Vomiting
Balance disorder

What are the existing conditions these people have? *

Pain: 8 people, 19.05%
High Blood Pressure: 8 people, 19.05%
High Blood Cholesterol: 6 people, 14.29%
Chest Pain: 6 people, 14.29%
Stress And Anxiety: 4 people, 9.52%
Neuralgia (pain in one or more nerves): 4 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.52%
Sleep Disorder: 3 people, 7.14%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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