Isosorbide mononitrate and Tolvaptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Isosorbide mononitrate (isosorbide mononitrate) and Tolvaptan (tolvaptan). Common drug interactions include atrial fibrillation among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Isosorbide mononitrate and Tolvaptan. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Tolvaptan?

Tolvaptan has active ingredients of tolvaptan. eHealthMe is studying from 5,685 Tolvaptan users. Check the latest studies of Tolvaptan.

On Jul, 12, 2026

29 people who take Isosorbide mononitrate and Tolvaptan together, and have interactions are studied.

Isosorbide mononitrate and Tolvaptan drug interactions.

What are the common drug interactions of Isosorbide Mononitrate and Tolvaptan, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pulmonary oedema (fluid accumulation in the lungs)
Viral infection
Blood sodium decreased
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Death
Abdominal distension
Cardiorenal syndrome (kidney failure and heart failure)
Cough

male:

Chest discomfort
Vertigo
Dyskinesia (abnormality or impairment of voluntary movement)
Electrocardiogram qt prolonged
Heat illness
Nausea (feeling of having an urge to vomit)
Blood glucose increased
Blood triglycerides increased
Cardiac failure
Glomerular filtration rate decreased

What are the common drug interactions of Isosorbide Mononitrate and Tolvaptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dizziness
Hepatitis (inflammation of the liver)
Blood creatinine increased
Blood glucose increased
Blood triglycerides increased
Glomerular filtration rate decreased
Hepatic enzyme increased
Hepatic steatosis (fatty liver disease)
High density lipoprotein decreased
Polyuria (production of too much dilute urine)

50-59:

Atrioventricular block first degree (heart block first degree)
Blood sodium decreased
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac failure
Hepatic congestion (liver congestion)
Hypotension (abnormally low blood pressure)
Oliguria (not enough urine)
Pulmonary congestion (congestion in the lungs)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Chest discomfort
Vertigo
Heat illness
Nausea (feeling of having an urge to vomit)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood sodium decreased
Dehydration (dryness resulting from the removal of water)
Pulmonary oedema (fluid accumulation in the lungs)
Viral infection
Death

What are the existing conditions these people have? *

Cardiac Failure Chronic: 11 people, 37.93%
Pre-Existing Disease: 5 people, 17.24%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 5 people, 17.24%
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls): 4 people, 13.79%
Cardiomyopathy (weakening of the heart muscle): 4 people, 13.79%
Platelet Aggregation Inhibition: 4 people, 13.79%
Blood Osmolarity Decreased: 4 people, 13.79%
High Blood Pressure: 4 people, 13.79%
Urination - Excessive Volume: 4 people, 13.79%
Coronary Artery Dilatation: 4 people, 13.79%

* Approximation only. Some reports may have incomplete information.

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