Ivermectin and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ivermectin (ivermectin) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include application site erythema among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Ivermectin and Hydroxyzine. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Ivermectin?

Ivermectin has active ingredients of ivermectin. eHealthMe is studying from 2,199 Ivermectin users. Check the latest studies of Ivermectin.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

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On Sep, 03, 2026

68 people who take Ivermectin and Hydroxyzine together, and have interactions are studied.

Ivermectin and Hydroxyzine drug interactions.

What are the common drug interactions of Ivermectin and Hydroxyzine, by gender? *:

female:

Application site erythema (redness of the skin at application site)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiovascular disorder (heart diseases)
Cholesteatoma (abnormal skin growth in the middle ear behind the eardrum)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

male:

Confusional state
Loss of consciousness
Leukocytosis (increased white blood cells)
Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Pain
Anal abscess

What are the common drug interactions of Ivermectin and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Amaurosis (partial or total blindness without visible change in the eye)
Aphasia (damage to the parts of the brain that control language)
Ataxia (loss of full control of bodily movements)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Echolalia (meaningless repetition of another person's spoken words -psychiatric disorder)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypertension (high blood pressure)

10-19:

n/a

20-29:

Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

30-39:

Skeletal injury (bone and supporting muscle injury)
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion
Venous injury
Visual impairment
Blood bilirubin increased
Discomfort
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Skin plaque (red, scaly patches to appear on the skin)

40-49:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Gangrene (body tissue dies)
Groin abscess (pus in groin)
Leukocytosis (increased white blood cells)
Scrotal abscess (pus in scrotum)
Testicular abscess (pus in testes)
Tooth abscess (pus formation in tooth)

50-59:

Asthma
Chronic kidney disease
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Eye inflammation
Mouth ulceration (mouth ulcers)
Rash
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Weight decreased

60+:

Headache (pain in head)
Drug ineffective
Application site erythema (redness of the skin at application site)
Blood bilirubin increased
Burning sensation
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiovascular disorder (heart diseases)
Cholesteatoma (abnormal skin growth in the middle ear behind the eardrum)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 20 people, 29.41%
Acarodermatitis (skin inflammation caused by mites (acarids)): 11 people, 16.18%
Hiv Infection: 8 people, 11.76%
Pain: 7 people, 10.29%
Asthma: 6 people, 8.82%
High Blood Pressure: 5 people, 7.35%
Depression: 5 people, 7.35%
Inflammation: 4 people, 5.88%
Infection: 4 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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