Methotrexate and Wegovy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Wegovy (semaglutide). Common drug interactions include irritable bowel syndrome among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Wegovy. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Wegovy?

Wegovy has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 4,887 Wegovy users. Check the latest studies of Wegovy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

15 people who take Methotrexate and Wegovy together, and have interactions are studied.

Methotrexate and Wegovy drug interactions.

What are the common drug interactions of Methotrexate and Wegovy, by gender? *:

female:

Irritable bowel syndrome
Limb injury
Migraine (headache)
Pain in extremity
Peripheral swelling
Stress
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood magnesium decreased
Blood potassium decreased
Arthralgia (joint pain)

male:

Abdominal pain
Abdominal pain upper
Diarrhoea
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Vomiting

What are the common drug interactions of Methotrexate and Wegovy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Abdominal pain upper
Blood thyroid stimulating hormone increased
Diarrhoea
Ear pain
Injection site pain
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Cystitis (inflammation of the wall of the bladder)
Drug ineffective
Dyspepsia (indigestion)
Fall
Fungal infection
Injection site erythema (redness at injection site)
Irritable bowel syndrome
Joint injury
Migraine (headache)
Neck injury

60+:

Pain
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 20.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 13.33%
Joint Pain: 2 people, 13.33%
Weakness: 1 person, 6.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 6.67%
Back Disorder: 1 person, 6.67%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 6.67%
Hair Loss: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and Wegovy?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously