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Jakafi and Clozapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Jakafi (ruxolitinib phosphate) and Clozapine (clozapine). Common drug interactions include abdominal pain among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Jakafi and Clozapine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Jakafi?

Jakafi has active ingredients of ruxolitinib phosphate. It is often used in primary myelofibrosis. eHealthMe is studying from 56,530 Jakafi users. Check the latest studies of Jakafi.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

On Jul, 11, 2026

12 people who take Jakafi and Clozapine together, and have interactions are studied.

Jakafi and Clozapine drug interactions.

What are the common drug interactions of Jakafi and Clozapine, by gender? *:

female:

  1. Abdominal pain
  2. Pyrexia (fever)
  3. Spleen disorder (disease of spleen)
  4. Abdominal pain upper
  5. Haemoglobin decreased
  6. Headache (pain in head)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Nausea (feeling of having an urge to vomit)
  9. Red blood cell count decreased
  10. White blood cell count decreased

male:

  1. Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Jakafi and Clozapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Neutropenia (an abnormally low number of neutrophils)

60+:

  1. Abdominal pain
  2. Herpes zoster
  3. Spleen disorder (disease of spleen)
  4. Abdominal pain upper
  5. Haemoglobin decreased
  6. Headache (pain in head)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Nausea (feeling of having an urge to vomit)
  9. Red blood cell count decreased
  10. White blood cell count decreased

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 25.00%
  2. Pain: 1 person, 8.33%
  3. Mania (a state of abnormally elevated or irritable mood): 1 person, 8.33%
  4. Full Blood Count Decreased: 1 person, 8.33%
  5. Anaemia (lack of blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Jakafi and Clozapine?

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- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Jakafi and Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Jakafi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Jakafi and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clozapine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on ruxolitinib phosphate and clozapine (the active ingredients of Jakafi and Clozapine, respectively), and Jakafi and Clozapine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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