Janumet and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Janumet (metformin hydrochloride; sitagliptin phosphate) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include urticaria among females and haemorrhage intracranial among males.

The phase IV clinical study analyzes what interactions people have when they take Janumet and Synjardy. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Jul, 30, 2026

21 people who take Janumet and Synjardy together, and have interactions are studied.

What are the common drug interactions of Janumet and Synjardy, by gender? *:

female:

Urticaria (rash of round, red welts on the skin that itch intensely)
Malaise (a feeling of general discomfort or uneasiness)
Anaphylactic reaction (serious allergic reaction)
Angioedema (rapid swelling of the dermis)
Asthma
Drug ineffective
Fear
Fluid retention (an abnormal accumulation of fluid in the blood)
Muscle spasms (muscle contraction)
Pain in extremity

male:

Haemorrhage intracranial (bleeding within the skull)
Abdominal discomfort
Micturition urgency (urgency to pass the urine)
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Dementia (madness)
Gait disturbance
General physical health deterioration (weak health status)
Scrotal abscess (pus in scrotum)
Scrotal swelling

What are the common drug interactions of Janumet and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)
Angioedema (rapid swelling of the dermis)
Asthma
Drug ineffective
Fear
Fluid retention (an abnormal accumulation of fluid in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Muscle spasms (muscle contraction)
Pain in extremity
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood glucose increased
Decreased appetite
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Ketoacidosis (high concentrations of ketone bodies in blood)
Nausea (feeling of having an urge to vomit)
Rash
Scrotal abscess (pus in scrotum)

60+:

Abdominal discomfort
Abdominal pain upper
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Dysuria (painful or difficult urination)
Fungal infection
Haemorrhage intracranial (bleeding within the skull)
Weight decreased
Blood glucose decreased

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 23.81%
Asthma: 3 people, 14.29%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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