Januvia and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Januvia (sitagliptin phosphate) and Ritalin (methylphenidate hydrochloride). Common drug interactions include weight increased among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Januvia and Ritalin. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

88 people who take Januvia and Ritalin together, and have interactions are studied.

What are the common drug interactions of Januvia and Ritalin, by gender? *:

female:

Weight increased
Abdominal discomfort
Anxiety
Arthropathy
Dry throat
Headache (pain in head)
Lacrimation increased
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Rash pruritic (redness with itching)
Alopecia (absence of hair from areas of the body)

male:

Arthralgia (joint pain)
Neuropathy peripheral (surface nerve damage)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hepatic steatosis (fatty liver disease)
Joint stiffness
Weight decreased
Adenocarcinoma pancreas (cancer of pancreas)
Anxiety

What are the common drug interactions of Januvia and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cough
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Confusional state
Hypoglycaemia (deficiency of glucose in the bloodstream)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute myocardial infarction (acute heart attack)
Adjustment disorder
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Dizziness
Hepatic steatosis (fatty liver disease)

50-59:

Adverse event
Anaemia (lack of blood)
Ataxia (loss of full control of bodily movements)
Blood glucose increased
Cardiac failure congestive
Chest pain
Coronary artery bypass
Diarrhoea
Dry skin
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Cough
Dry mouth
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Eye haemorrhage (bleeding in the eye)
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 33 people, 37.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 19.32%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 15 people, 17.05%
Type 2 Diabetes: 12 people, 13.64%
High Blood Pressure: 12 people, 13.64%
High Blood Cholesterol: 12 people, 13.64%
Depression: 8 people, 9.09%
Pain: 6 people, 6.82%
Sleep Disorder: 5 people, 5.68%
Multiple Myeloma (cancer of the plasma cells): 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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