Jardiance and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Jardiance (empagliflozin) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include lip injury among females and coronary artery disease among males.

The phase IV clinical study analyzes what interactions people have when they take Jardiance and Flexeril. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Jardiance?

Jardiance has active ingredients of empagliflozin. It is often used in hyperglycemia. eHealthMe is studying from 44,457 Jardiance users. Check the latest studies of Jardiance.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 15, 2026

63 people who take Jardiance and Flexeril together, and have interactions are studied.

Jardiance and Flexeril drug interactions.

What are the common drug interactions of Jardiance and Flexeril, by gender? *:

female:

Lip injury
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)
Peripheral swelling
Somnambulism (sleep walking)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tremor (trembling or shaking movements in one or more parts of your body)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Type 2 diabetes mellitus

male:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Diarrhoea
Immune system disorder
Neuropathy peripheral (surface nerve damage)
Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Coronary artery stenosis (narrowing of coronary artery)
Hepatocellular carcinoma (liver cancer)
Intestinal obstruction

What are the common drug interactions of Jardiance and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Loss of consciousness
Abdominal distension
Blood cholesterol increased
Blood potassium decreased
Chest pain
Constipation
Dehydration (dryness resulting from the removal of water)
Endocarditis (inflammation in heart muscle)
Fluid retention (an abnormal accumulation of fluid in the blood)

50-59:

Nephrolithiasis (calculi in the kidneys)
Pain in extremity
Pneumonia
Pyrexia (fever)
Rash pruritic (redness with itching)
Streptococcal sepsis (whole body inflammation by streptococcal)
Thrombocytosis
Urinary tract infection
Urinary tract obstruction
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

60+:

Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Blood glucose increased
Blood pressure increased
Blood sodium increased
Blood urine present
Cartilage injury
Cellulitis (infection under the skin)
Decreased appetite
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Type 2 Diabetes: 27 people, 42.86%
Pain: 15 people, 23.81%
High Blood Pressure: 15 people, 23.81%
Diabetes: 9 people, 14.29%
High Blood Cholesterol: 9 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.52%
Back Pain: 6 people, 9.52%
Asthma: 6 people, 9.52%
Nausea (feeling of having an urge to vomit): 5 people, 7.94%
Infection: 5 people, 7.94%

* Approximation only. Some reports may have incomplete information.

Do you take Jardiance and Flexeril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously