Kaletra and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kaletra (lopinavir; ritonavir) and Methotrexate (methotrexate sodium). Common drug interactions include diarrhoea among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Kaletra and Methotrexate. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Kaletra?

Kaletra has active ingredients of lopinavir; ritonavir. It is often used in hiv infection. eHealthMe is studying from 23,070 Kaletra users. Check the latest studies of Kaletra.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

52 people who take Kaletra and Methotrexate together, and have interactions are studied.

Kaletra and Methotrexate drug interactions.

What are the common drug interactions of Kaletra and Methotrexate, by gender? *:

female:

Diarrhoea
Emotional distress
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Haematuria (presence of blood in urine)
Hallucination (an experience involving the perception of something not present)
Intra-uterine death
Leukaemia (blood or bone marrow cancer)
Lung infection pseudomonal (bacterial infection of lung by pseudomonas aeruginosa)
Mucosal haemorrhage (bleeding from mucous membrane)
Mucosal inflammation (infection of mucous membrane)

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure acute (rapid kidney dysfunction)
Umbilical cord vascular disorder
Leukopenia (less number of white blood cells in blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Breech presentation
Emotional distress
Hypertriglyceridaemia (excess of triglycerides in the blood)
Low birth weight baby

What are the common drug interactions of Kaletra and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Melaena (the passage of black, tarry stools)
Mucosal haemorrhage (bleeding from mucous membrane)
Multi-organ failure (multisystem organ failure)
Muscle rigidity (muscle stiffness)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Spinal compression fracture (fracture due to spinal compression on bone)

40-49:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Abortion spontaneous (naturally occurring miscarriage)
Ankle fracture

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Anaemia (lack of blood)
Cachexia (loss of weight)
Depression
Diarrhoea

60+:

Renal failure acute (rapid kidney dysfunction)
Acute hepatic failure
Lung infection pseudomonal (bacterial infection of lung by pseudomonas aeruginosa)
Multi-organ failure (multisystem organ failure)
Organ failure
Polyhydramnios (excess of amniotic fluid in the amniotic sac)
Pregnancy
Premature baby
Premature delivery
Premature rupture of membranes

What are the existing conditions these people have? *

Hiv Infection: 30 people, 57.69%
Staphylococcal Bacteraemia (a bacterial infection of blood): 5 people, 9.62%
Hiv Test Positive: 5 people, 9.62%
Hepatitis B: 5 people, 9.62%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 9.62%
Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 5 people, 9.62%
Lower Respiratory Tract Infection: 4 people, 7.69%
Joint Pain: 4 people, 7.69%
Fungal Infection: 4 people, 7.69%
Arthropathy: 4 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Kaletra and Methotrexate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously