Kalydeco and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kalydeco (ivacaftor) and Levaquin (levofloxacin). Common drug interactions include infective pulmonary exacerbation of cystic fibrosis among females and blood creatine phosphokinase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Kalydeco and Levaquin. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Kalydeco?

Kalydeco has active ingredients of ivacaftor. eHealthMe is studying from 6,652 Kalydeco users. Check the latest studies of Kalydeco.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Jul, 29, 2026

19 people who take Kalydeco and Levaquin together, and have interactions are studied.

Kalydeco and Levaquin drug interactions.

What are the common drug interactions of Kalydeco and Levaquin, by gender? *:

female:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Abdominal pain upper
Anxiety
Asthma
Chest discomfort
Constipation
Drug hypersensitivity
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Blood creatine phosphokinase increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatitis (inflammation of the liver)
Post procedural haematoma (post procedural clotting of blood)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pulmonary function test decreased
Pulmonary haemorrhage (acute bleeding from the lung)
Respiratory disorder (respiratory disease)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Seasonal allergy (allergic condition due to certain season)

What are the common drug interactions of Kalydeco and Levaquin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fungal infection

20-29:

Blood creatine phosphokinase increased
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

30-39:

Anxiety
Asthma
Chest discomfort
Constipation
Drug hypersensitivity
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Upper respiratory tract infection
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pulmonary function test decreased
Pulmonary haemorrhage (acute bleeding from the lung)

50-59:

Cystic fibrosis (disease of the secretary glands)
Intestinal obstruction
Oral discomfort (pain or irritation in mouth)
Pain in extremity

60+:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 14 people, 73.68%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 10 people, 52.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 26.32%
Infective Pulmonary Exacerbation Of Cystic Fibrosis (severe infective lung disease with production of abnormally thick mucus): 4 people, 21.05%
Constipation: 4 people, 21.05%
Asthma: 3 people, 15.79%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 3 people, 15.79%
Pancreatic Insufficiency: 3 people, 15.79%
Pain: 3 people, 15.79%
Nausea (feeling of having an urge to vomit): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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