Keppra and Cresemba drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Keppra (levetiracetam) and Cresemba (isavuconazonium sulfate). Common drug interactions include dizziness among females and pyrexia among males.
The phase IV clinical study analyzes what interactions people have when they take Keppra and Cresemba. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
What is Cresemba?
Cresemba has active ingredients of isavuconazonium sulfate. eHealthMe is studying from 2,574 Cresemba users. Check the latest studies of Cresemba.
39 people who take Keppra and Cresemba together, and have interactions are studied.

What are the common drug interactions of Keppra and Cresemba, by gender? *:
female:
- Dizziness
- Dyspnoea (difficult or laboured respiration)
- Fall
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Hyperglycaemia (high blood sugar)
- Klebsiella infection
- Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
- Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
- Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
male:
- Pyrexia (fever)
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
- C-reactive protein increased
- Chest pain
- Electrocardiogram qt prolonged
- Fatigue (feeling of tiredness)
- Febrile neutropenia (fever with reduced white blood cells)
- Gait disturbance
- Headache (pain in head)
What are the common drug interactions of Keppra and Cresemba, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Abdominal pain
- Cardiac arrest
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
- Hyperkalaemia (damage to or disease of the kidney)
- Polydipsia (excessive thirst)
- Hyperglycaemia (high blood sugar)
10-19:
- Hyperkalaemia (damage to or disease of the kidney)
- Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
- Hypocalcaemia (levels of calcium in blood serum are abnormally low)
- Hypotension (abnormally low blood pressure)
- Hypoxia (low oxygen in tissues)
- Melaena (the passage of black, tarry stools)
- Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
- Neutropenia (an abnormally low number of neutrophils)
- Pericardial effusion (fluid around the heart)
- Pulmonary haemorrhage (acute bleeding from the lung)
20-29:
- Chloroma (green-coloured tumour)
- Acute lymphocytic leukaemia (cancer of the white blood cells)
- Acute myelomonocytic leukaemia (cancer of the blood-forming organs)
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Depressed level of consciousness
- Haematocrit decreased
- Haemoglobin decreased
- Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
- Hypotension (abnormally low blood pressure)
- Hypoxia (low oxygen in tissues)
30-39:
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Death
- Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
40-49:
- Blood bilirubin increased
- Confusional state
- Creatinine renal clearance decreased
- Delirium (wild excitement)
- Disorientation (disability in which the senses of time, direction, and recognition of people and places)
- Eye swelling
- Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
- Mucosal inflammation (infection of mucous membrane)
- Neutropenia (an abnormally low number of neutrophils)
- Orbital oedema (swelling of orbit)
50-59:
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Klebsiella infection
60+:
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
- Gait disturbance
- Haemoglobin decreased
- Headache (pain in head)
- Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
- Hypotension (abnormally low blood pressure)
- Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
- Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
- Malaise (a feeling of general discomfort or uneasiness)
What are the existing conditions these people have? *
- Diabetes: 8 people, 20.51%
- Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina): 8 people, 20.51%
- Insomnia (sleeplessness): 8 people, 20.51%
- Bacterial Infection: 8 people, 20.51%
- Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 7 people, 17.95%
- Nausea (feeling of having an urge to vomit): 5 people, 12.82%
- Indigestion: 5 people, 12.82%
- Fever: 5 people, 12.82%
- Pain: 5 people, 12.82%
- Constipation: 5 people, 12.82%
* Approximation only. Some reports may have incomplete information.
Do you take Keppra and Cresemba?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Keppra and Cresemba:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cresemba:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cresemba and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on levetiracetam and isavuconazonium sulfate (the active ingredients of Keppra and Cresemba, respectively), and Keppra and Cresemba (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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