Keppra and Gleevec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra (levetiracetam) and Gleevec (imatinib mesylate). Common drug interactions include fatigue among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra and Gleevec. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

On Jul, 11, 2026

79 people who take Keppra and Gleevec together, and have interactions are studied.

What are the common drug interactions of Keppra and Gleevec, by gender? *:

female:

Fatigue (feeling of tiredness)
Rash
Death
Malignant neoplasm progression (cancer tumour came back)
Muscle spasms (muscle contraction)
Anxiety
Depression
Diarrhoea
Myalgia (muscle pain)
Pain

male:

Asthenia (weakness)
Death
Alanine aminotransferase increased
Aspartate aminotransferase increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Heart rate increased
Hemiparesis (weakness on one side of the body)

What are the common drug interactions of Keppra and Gleevec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Bacterascites (bacterial infection of ascetic fluid)
Blood pressure decreased
Cardiac murmur (an heart sound in valve abnormality)
Depression
Dyspnoea (difficult or laboured respiration)
Eating disorder
Fatigue (feeling of tiredness)

20-29:

Abdominal hernia
Alopecia (absence of hair from areas of the body)
Coma (state of unconsciousness lasting more than six hours)
Death
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Iodine allergy
Renal failure (kidney dysfunction)
Vomiting

30-39:

Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Muscle contractions involuntary (uncontrolled muscle contraction)
Muscle spasms (muscle contraction)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Disturbance in attention
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea exertional (breathlessness or shortness of breath)

40-49:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cough
Headache (pain in head)
Hydrocephalus (water on the brain)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Nausea (feeling of having an urge to vomit)
Pulmonary oedema (fluid accumulation in the lungs)
Alanine aminotransferase increased

50-59:

Blood albumin decreased
Blood bilirubin increased
Blood calcium decreased
Blood phosphorus decreased
Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Glomerular filtration rate decreased
Haematocrit decreased
Haemoglobin decreased
Haemorrhage intracranial (bleeding within the skull)

60+:

Asthenia (weakness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Brain neoplasm (tumour of brain)
Death
Fatigue (feeling of tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pleural effusion (water on the lungs)
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 15 people, 18.99%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 11 people, 13.92%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 10.13%
Gastrointestinal Stromal Tumor: 6 people, 7.59%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 5 people, 6.33%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 5 people, 6.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 5.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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