Keppra and Relafen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keppra (levetiracetam) and Relafen (nabumetone). Common drug interactions include intervertebral disc protrusion among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Keppra and Relafen. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

On Jul, 26, 2026

19 people who take Keppra and Relafen together, and have interactions are studied.

What are the common drug interactions of Keppra and Relafen, by gender? *:

female:

Intervertebral disc protrusion (spinal disc protrusion)
Laryngitis (inflammation of the larynx)
Leukopenia (less number of white blood cells in blood)
Leukoplakia (white and gray patches inside the mouth)
Limb discomfort (discomfort in leg)
Lip disorder (disease of lip)
Lumbar vertebral fracture
Headache (pain in head)
Ataxia (loss of full control of bodily movements)
Confusional state

male:

Arrhythmia (irregular heartbeat)
Avulsion fracture (bone fracture)
Oedema (fluid collection in tissue)
Personality disorder
Type 2 diabetes mellitus
Unresponsive to stimuli
Back pain
Contusion (a type of hematoma of tissue in which capillaries)
Death
Drug toxicity

What are the common drug interactions of Keppra and Relafen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Avulsion fracture (bone fracture)
Back pain
Blood alkaline phosphatase increased
Contusion (a type of hematoma of tissue in which capillaries)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Hypersensitivity
Intervertebral disc degeneration (spinal disc degeneration)

40-49:

Arrhythmia (irregular heartbeat)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Drug toxicity
Dysphagia (a condition in which swallowing is difficult or painful)
Hunger
Interstitial lung disease
Nausea (feeling of having an urge to vomit)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

50-59:

Hypersomnia (excessive daytime sleepiness (eds))
Hypertension (high blood pressure)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypotension (abnormally low blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Limb discomfort (discomfort in leg)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Memory impairment
Migraine (headache)
Myopathy (a muscular disease in which the muscle fibres do not function)

60+:

Confusional state
Aggression
Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Tremor (trembling or shaking movements in one or more parts of your body)
Dysphagia (a condition in which swallowing is difficult or painful)
Anaemia (lack of blood)
Cardiac arrest
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

What are the existing conditions these people have? *

Pain: 6 people, 31.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
Infection: 2 people, 10.53%
Muscle Aches (muscle pain): 2 people, 10.53%
Muscle Spasms (muscle contraction): 2 people, 10.53%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 10.53%
Osteoporosis (bones weak and more likely to break): 2 people, 10.53%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 10.53%
Pneumonia: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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