Ketamine hcl and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketamine hcl (ketamine hydrochloride) and Methotrexate (methotrexate sodium). Common drug interactions include hypernatraemia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Ketamine hcl and Methotrexate. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Ketamine hcl?

Ketamine hcl has active ingredients of ketamine hydrochloride. It is often used in pain. eHealthMe is studying from 1,851 Ketamine hcl users. Check the latest studies of Ketamine hcl.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 15, 2026

31 people who take Ketamine hcl and Methotrexate together, and have interactions are studied.

Ketamine hcl and Methotrexate drug interactions.

What are the common drug interactions of Ketamine Hcl and Methotrexate, by gender? *:

female:

Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Infection
Cerebral haemorrhage (bleeding within the brain)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Chest discomfort

male:

Headache (pain in head)
Diarrhoea
Oxygen saturation decreased
Anxiety
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)
Neurological symptom (symptoms of nervous system disease)
Respiratory depression (respiration has a rate below 12 breaths)

What are the common drug interactions of Ketamine Hcl and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Vomiting
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Confusional state
Cough
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Neurological symptom (symptoms of nervous system disease)
Respiratory depression (respiration has a rate below 12 breaths)

10-19:

Acute respiratory distress syndrome
Blood bilirubin increased
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Lung neoplasm (tumour of lung)

20-29:

Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac arrest
Circulatory collapse
Coagulopathy (blood's ability to clot is impaired)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Diplopia (double vision)
Encephalitis (inflammation of the brain)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Enterobacter test positive

30-39:

Fibromyalgia (a long-term condition which causes pain all over the body)

40-49:

n/a

50-59:

Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Anxiety
Aortic dilatation
Arthralgia (joint pain)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Abscess (pus)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Red blood cell count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)
Drug ineffective
Hyperaesthesia
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 10 people, 32.26%
Cough: 6 people, 19.35%
Sedation: 5 people, 16.13%
Nausea (feeling of having an urge to vomit): 5 people, 16.13%
Constipation: 5 people, 16.13%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.90%
Multiple Allergies (allergy to multiple agents): 4 people, 12.90%
Agitation (state of anxiety or nervous excitement): 4 people, 12.90%
Anaemia (lack of blood): 4 people, 12.90%
Anaesthesia: 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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