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Kevzara and Otrexup drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kevzara (sarilumab) and Otrexup (methotrexate). Common drug interactions include infection among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Kevzara and Otrexup. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Kevzara?

Kevzara has active ingredients of sarilumab. eHealthMe is studying from 17,561 Kevzara users. Check the latest studies of Kevzara.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

On Jul, 15, 2026

15 people who take Kevzara and Otrexup together, and have interactions are studied.

Kevzara and Otrexup drug interactions.

What are the common drug interactions of Kevzara and Otrexup, by gender? *:

female:

  1. Infection
  2. Abdominal discomfort
  3. Alopecia (absence of hair from areas of the body)
  4. Arthropathy
  5. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  6. Discomfort
  7. Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
  8. Hypersensitivity
  9. Impaired work ability
  10. Limb injury

male:

  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Stomatitis (inflammation of mucous membrane of mouth)
  4. Vomiting

What are the common drug interactions of Kevzara and Otrexup, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Rash
  2. Urinary tract infection

40-49:

  1. Pain
  2. Abdominal discomfort
  3. Alopecia (absence of hair from areas of the body)
  4. Arthropathy
  5. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  6. Discomfort
  7. Drug ineffective
  8. Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
  9. Hepatic enzyme increased
  10. Hypersensitivity

50-59:

  1. Infection
  2. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  3. Vomiting
  4. Fatigue (feeling of tiredness)
  5. Nausea (feeling of having an urge to vomit)
  6. Stomatitis (inflammation of mucous membrane of mouth)
  7. Drug ineffective

60+:

  1. Dizziness
  2. Drug ineffective
  3. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  4. Pain
  5. Peripheral coldness
  6. Sensory disturbance (sense disturbance)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 80.00%
  2. Osteoporosis (bones weak and more likely to break): 1 person, 6.67%
  3. Arthropathy: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Kevzara and Otrexup?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Kevzara and Otrexup:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Kevzara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Otrexup:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Kevzara and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Otrexup and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sarilumab and methotrexate (the active ingredients of Kevzara and Otrexup, respectively), and Kevzara and Otrexup (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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