Keytruda and Diclofenac sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Diclofenac sodium (diclofenac sodium). Common drug interactions include thrombocytopenia among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Diclofenac sodium. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Diclofenac sodium?

Diclofenac sodium has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 43,018 Diclofenac sodium users. Check the latest studies of Diclofenac sodium.

On Aug, 12, 2026

47 people who take Keytruda and Diclofenac sodium together, and have interactions are studied.

Keytruda and Diclofenac sodium drug interactions.

What are the common drug interactions of Keytruda and Diclofenac Sodium, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hypertension (high blood pressure)
Malignant neoplasm progression (cancer tumour came back)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Rash
Stomatitis (inflammation of mucous membrane of mouth)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Cytomegalovirus enterocolitis (virus infection of intestine and colon)

male:

Decreased appetite
Interstitial lung disease
Weight decreased
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Anxiety disorder
Blood creatinine increased
Blood pressure increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Fatigue (feeling of tiredness)
Hyperkalaemia (damage to or disease of the kidney)

What are the common drug interactions of Keytruda and Diclofenac Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Death
Hypertension (high blood pressure)
Pneumonia
Rash
Thyroiditis (inflammation of thyroid gland)

50-59:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Malignant neoplasm progression (cancer tumour came back)
Abdominal pain
Cholangitis sclerosing (infection and obstruction of bile duct)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Skin lesion
Arthralgia (joint pain)
Back pain
Blood pressure fluctuation

60+:

Interstitial lung disease
Decreased appetite
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Abdominal pain
Anxiety disorder
Blood creatinine increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Hyperkalaemia (damage to or disease of the kidney)
Malignant neoplasm progression (cancer tumour came back)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 6 people, 12.77%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 5 people, 10.64%
Endometrial Cancer: 5 people, 10.64%
Pneumonia: 3 people, 6.38%
Pain: 3 people, 6.38%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 3 people, 6.38%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.38%
High Blood Pressure: 3 people, 6.38%
Cancer Pain: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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