Keytruda and Trulicity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Keytruda (pembrolizumab) and Trulicity (dulaglutide). Common drug interactions include fatigue among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Keytruda and Trulicity. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

57 people who take Keytruda and Trulicity together, and have interactions are studied.

Keytruda and Trulicity drug interactions.

What are the common drug interactions of Keytruda and Trulicity, by gender? *:

female:

Fatigue (feeling of tiredness)
Diarrhoea
Headache (pain in head)
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
Thrombosis (formation of a blood clot inside a blood vessel)
Abdominal discomfort
Back pain
Blindness
Chest pain
Gallbladder disorder

male:

Diarrhoea
Peripheral swelling
Arthralgia (joint pain)
Blood glucose increased
Cardiac failure
Dehydration (dryness resulting from the removal of water)
Gait disturbance
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Keytruda and Trulicity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Chest pain
Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pineal gland cyst
Vomiting

50-59:

Abdominal discomfort
Fatigue (feeling of tiredness)
Headache (pain in head)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Pneumonia
Rash
Renal impairment (severely reduced kidney function)
Arthralgia (joint pain)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Blood glucose increased
C-reactive protein increased

What are the existing conditions these people have? *

Lung Adenocarcinoma (a form of non-small cell lung cancer): 12 people, 21.05%
Diabetes: 8 people, 14.04%
Lung Cancer - Non-Small Cell (lung cancer): 7 people, 12.28%
Type 2 Diabetes: 5 people, 8.77%
Pain: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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