Klonopin and Adderall 20 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Klonopin (clonazepam) and Adderall 20 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include tremor among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Klonopin and Adderall 20. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Adderall 20?

Adderall 20 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,719 Adderall 20 users. Check the latest studies of Adderall 20.



On Aug, 12, 2026

13 people who take Klonopin and Adderall 20 together, and have interactions are studied.

Klonopin and Adderall 20 drug interactions.

What are the common drug interactions of Klonopin and Adderall 20, by gender? *:

female:

  1. Tremor (trembling or shaking movements in one or more parts of your body)
  2. Dizziness
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. Headache (pain in head)
  5. Joint swelling
  6. Nausea (feeling of having an urge to vomit)
  7. Abdominal pain upper
  8. Activities of daily living impaired
  9. Adverse event
  10. Alanine aminotransferase increased

male:

  1. Blood pressure increased
  2. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  3. Dizziness
  4. Epigastric discomfort
  5. Fall
  6. Infusion site reaction
  7. Vertigo
  8. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  9. Asthenia (weakness)
  10. Body temperature decreased

What are the common drug interactions of Klonopin and Adderall 20, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood pressure increased
  2. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  3. Confusional state
  4. Difficulty in walking
  5. Fatigue (feeling of tiredness)
  6. Heart rate increased
  7. Hypersensitivity
  8. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  9. Pyrexia (fever)
  10. Chest discomfort

30-39:

n/a

40-49:

  1. Headache (pain in head)
  2. Nausea (feeling of having an urge to vomit)
  3. Burning sensation
  4. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  5. Cholesterosis (abnormal deposition of cholesterol in tissues)
  6. Dizziness
  7. Dyspnoea (difficult or laboured respiration)
  8. Fatigue (feeling of tiredness)
  9. Heart rate increased
  10. Influenza like illness

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 23.08%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 15.38%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 15.38%
  4. Bipolar Disorder (mood disorder): 2 people, 15.38%
  5. Quit Smoking: 1 person, 7.69%
  6. Personality Disorder: 1 person, 7.69%
  7. Panic Disorder: 1 person, 7.69%
  8. Pain: 1 person, 7.69%
  9. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
  10. Insomnia (sleeplessness): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Klonopin and Adderall 20:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Klonopin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Adderall 20:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Klonopin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adderall 20 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on clonazepam and amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Klonopin and Adderall 20, respectively), and Klonopin and Adderall 20 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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