Konakion and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Konakion (phytonadione) and Methotrexate (methotrexate sodium). Common drug interactions include hepatic haematoma among females and graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Konakion and Methotrexate. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Konakion?

Konakion has active ingredients of phytonadione. eHealthMe is studying from 1,342 Konakion users. Check the latest studies of Konakion.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 27, 2026

55 people who take Konakion and Methotrexate together, and have interactions are studied.

Konakion and Methotrexate drug interactions.

What are the common drug interactions of Konakion and Methotrexate, by gender? *:

female:

Hepatic haematoma (collection of blood outside of blood vessels in liver)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Joint swelling
Mendelson's syndrome (chemical inflammation of lung caused by aspiration during anaesthesia)
Monoparesis (one limb is very weak, but not completely paralyzed)
Pancreatitis (inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleural effusion (water on the lungs)
Rash macular (small, flat red spots)
Renal disorder (kidney disease)

male:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Ascites (accumulation of fluid in the abdominal cavity)
Oedema (fluid collection in tissue)
Rash erythematous (redness of the skin)
Upper respiratory tract infection
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Stridor
Angioedema (rapid swelling of the dermis)

What are the common drug interactions of Konakion and Methotrexate, by age (0-1 to 60+)? *:

0-1:

Ascites (accumulation of fluid in the abdominal cavity)
Acute circulatory failure (shock)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Mucosal haemorrhage (bleeding from mucous membrane)
Oedema (fluid collection in tissue)
Pyrexia (fever)
Skin ulcer

2-9:

Consciousness fluctuating
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haemorrhage (bleeding)
Mucosal erosion (peeling off of mucous membrane)
Mucosal inflammation (infection of mucous membrane)
Pancreatitis (inflammation of pancreas)

10-19:

Hypoaesthesia (reduced sense of touch or sensation)
Pain in limb
Diplegia (paralysis of corresponding parts on both sides of the body)
Haemorrhage intracranial (bleeding within the skull)
Monoparesis (one limb is very weak, but not completely paralyzed)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

20-29:

Aplasia (defective development or congenital absence of an organ or tissue)
Bacteraemia (presence of bacteria in the blood)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Hyperglycaemia (high blood sugar)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)

30-39:

Cardiac failure
Cardiomyopathy (weakening of the heart muscle)
Cholangitis (infection of the bile duct)
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Hepatic haematoma (collection of blood outside of blood vessels in liver)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Mendelson's syndrome (chemical inflammation of lung caused by aspiration during anaesthesia)
Pleural effusion (water on the lungs)
Pneumonia
Rash macular (small, flat red spots)

40-49:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Conjunctivitis (pink eye)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Multi-organ failure (multisystem organ failure)
Rash macular (small, flat red spots)
Pyrexia (fever)

50-59:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Gastroenteritis (inflammation of stomach and intestine)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Mucosal inflammation (infection of mucous membrane)
Pneumonia
Pyrexia (fever)
Rash erythematous (redness of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Altered state of consciousness (altered state of mind)
Encephalitis (inflammation of the brain)
Bacteraemia (presence of bacteria in the blood)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pyrexia (fever)
Cellulitis (infection under the skin)
Joint swelling
Encephalopathy (functioning of the brain is affected by some agent or condition)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

What are the existing conditions these people have? *

Pain: 21 people, 38.18%
Oedema (fluid collection in tissue): 21 people, 38.18%
Fungal Infection: 19 people, 34.55%
Hypokalemia (low potassium): 19 people, 34.55%
Nausea (feeling of having an urge to vomit): 17 people, 30.91%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 15 people, 27.27%
Heart Disease: 15 people, 27.27%
Urinary Tract Infection: 14 people, 25.45%
Bleeding Disorders: 14 people, 25.45%
Conjunctivitis (pink eye): 14 people, 25.45%

* Approximation only. Some reports may have incomplete information.

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