Korlym and Lexapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Korlym (mifepristone) and Lexapro (escitalopram oxalate). Common drug interactions include incontinence among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Korlym and Lexapro. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Korlym?

Korlym has active ingredients of mifepristone. eHealthMe is studying from 3,078 Korlym users. Check the latest studies of Korlym.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

85 people who take Korlym and Lexapro together, and have interactions are studied.

What are the common drug interactions of Korlym and Lexapro, by gender? *:

female:

Incontinence (lack of moderation or self-control)
Abdominal distension
Abdominal pain upper
Irritability
Menstrual disorder (disease of menstrual cycle)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia viral
Renal impairment (severely reduced kidney function)
Septic shock (shock due to blood infection)

male:

Weight increased
Weight decreased
Loss of consciousness
Metastatic neoplasm (spreadable cancer tumour)
Neuralgia (pain in one or more nerves)
Osteoporosis (bones weak and more likely to break)
Peripheral swelling
Upper limb fracture
Decreased appetite
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Korlym and Lexapro, by age (0-1 to 60+)? *:

0-1:

Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Decreased appetite
Depressed mood
Headache (pain in head)
Insomnia (sleeplessness)
Retching (strong involuntary effort to vomit)

2-9:

n/a

10-19:

n/a

20-29:

Blood potassium decreased
Oedema peripheral (superficial swelling)
Vomiting
Blood magnesium decreased
Confusional state
Cyst (a closed sac)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Mass
Muscle twitching
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Decreased appetite
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Fatigue (feeling of tiredness)
Peripheral swelling
Abdominal distension
Asthenia (weakness)
Blood bilirubin increased
Essential thrombocythaemia (chronic blood cancer)

40-49:

Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal distension
Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Vomiting
Weight increased

50-59:

Syncope (loss of consciousness with an inability to maintain postural tone)
Asthenia (weakness)
Back pain
Blood calcium increased
Blood glucose decreased
Blood pressure increased
Blood thyroid stimulating hormone decreased
Decreased appetite
Dry mouth
Hepatic enzyme increased

60+:

Headache (pain in head)
Vomiting
Contusion (a type of hematoma of tissue in which capillaries)
International normalised ratio increased
Peripheral swelling
Blood potassium decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bursa disorder
Cardiac failure congestive
Faeces discoloured

What are the existing conditions these people have? *

Cushing's Syndrome (obesity, a rounded face, increased fat): 63 people, 74.12%
Pituitary-Dependent Cushing's Syndrome (pituitary dependent hypercortisolism): 16 people, 18.82%

* Approximation only. Some reports may have incomplete information.

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