Korlym and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Korlym (mifepristone) and Profen (ibuprofen). Common drug interactions include joint swelling among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Korlym and Profen. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Korlym?

Korlym has active ingredients of mifepristone. eHealthMe is studying from 3,078 Korlym users. Check the latest studies of Korlym.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

70 people who take Korlym and Profen together, and have interactions are studied.

What are the common drug interactions of Korlym and Profen, by gender? *:

female:

Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Nasal polyps (masses that develop in the lining of the nose)
Piloerection (goose bumps)
Procedural pain
Protein total decreased
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Swelling
Uterine polyp (a mass in the inner lining of the uterus)

male:

Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Aggression
Asthenia (weakness)
Aura
Blood calcium increased
Blood glucose decreased
Blood glucose fluctuation
Blood glucose increased
Blood thyroid stimulating hormone decreased

What are the common drug interactions of Korlym and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Agitation (state of anxiety or nervous excitement)
Abdominal pain lower
Acne (skin problems that cause pimples)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Arthralgia (joint pain)
Blood glucose fluctuation
Blood pressure fluctuation
Blood pressure increased
Blood urine present
Constipation

40-49:

Vaginal haemorrhage (vaginal bleeding)
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Blood glucose decreased
Blood potassium decreased
Headache (pain in head)
Hyperthyroidism (over activity of the thyroid gland)
Vomiting
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)

50-59:

Blood pressure decreased
Blood pressure increased
Breast tenderness
Glycosylated haemoglobin increased
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Influenza
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Streptococcal urinary tract infection (a bacterial infection of urinary tract)

60+:

Blood pressure increased
Fatigue (feeling of tiredness)
Constipation
Fluid retention (an abnormal accumulation of fluid in the blood)
Renal impairment (severely reduced kidney function)
Vascular occlusion (sudden blockage of a blood vessel, usually with a clot)
Diarrhoea
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Blood potassium decreased

What are the existing conditions these people have? *

Cushing's Syndrome (obesity, a rounded face, increased fat): 61 people, 87.14%
Pituitary-Dependent Cushing's Syndrome (pituitary dependent hypercortisolism): 5 people, 7.14%
Type 2 Diabetes: 4 people, 5.71%
High Blood Pressure: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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