Kyprolis and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kyprolis (carfilzomib) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include dyspnoea among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Kyprolis and Flexeril. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Kyprolis?

Kyprolis has active ingredients of carfilzomib. It is often used in multiple myeloma. eHealthMe is studying from 15,080 Kyprolis users. Check the latest studies of Kyprolis.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 10, 2026

28 people who take Kyprolis and Flexeril together, and have interactions are studied.

Kyprolis and Flexeril drug interactions.

What are the common drug interactions of Kyprolis and Flexeril, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Gait disturbance
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza
Lactose intolerance (inability to digest lactose)
Lung infection
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)

male:

Pneumonia
Anaemia (lack of blood)
Electrolyte imbalance
Gait disturbance
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypertension (high blood pressure)
Leukopenia (less number of white blood cells in blood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Bacterial sepsis

What are the common drug interactions of Kyprolis and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone pain
Hypoaesthesia (reduced sense of touch or sensation)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

40-49:

Swelling face
Exfoliative rash (scaly red generalized skin rash)
Rash
Rash macular (small, flat red spots)

50-59:

Leukopenia (less number of white blood cells in blood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mobility decreased (ability to move is reduced)
Pain
Pneumonia
Arthralgia (joint pain)
Diarrhoea
Fatigue (feeling of tiredness)
Infusion site pain
Light chain analysis increased

60+:

Pneumonia
Diarrhoea
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Rash
Abdominal distension
Acute respiratory distress syndrome
Acute respiratory failure

What are the existing conditions these people have? *

Pain: 8 people, 28.57%
High Blood Pressure: 6 people, 21.43%
Neuropathy Peripheral (surface nerve damage): 4 people, 14.29%
Herpes Zoster: 3 people, 10.71%
Nausea (feeling of having an urge to vomit): 3 people, 10.71%
High Blood Cholesterol: 3 people, 10.71%
Erection Problems: 2 people, 7.14%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 7.14%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 7.14%
Constipation: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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