L-methylfolate and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take L-methylfolate (folic acid) and Modafinil (modafinil). Common drug interactions include anxiety among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take L-methylfolate and Modafinil. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is L-methylfolate?

L-methylfolate has active ingredients of folic acid. It is often used in depression. eHealthMe is studying from 619 L-methylfolate users. Check the latest studies of L-methylfolate.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 14, 2026

27 people who take L-methylfolate and Modafinil together, and have interactions are studied.

L-methylfolate and Modafinil drug interactions.

What are the common drug interactions of L-Methylfolate and Modafinil, by gender? *:

female:

Anxiety
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Neuralgia (pain in one or more nerves)
Blood pressure increased
Drug ineffective
Exfoliative rash (scaly red generalized skin rash)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Rash erythematous (redness of the skin)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Shrinking lung syndrome (decrease lung capacity due to lupus (a collection of autoimmune diseases))

male:

Diarrhoea
Abdominal discomfort
Bipolar disorder (mood disorder)
Cardiac procedure complication
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Hepatic steatosis (fatty liver disease)
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Muscle rigidity (muscle stiffness)

What are the common drug interactions of L-Methylfolate and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Anxiety
Diarrhoea
Energy increased
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Therapeutic response unexpected
Bipolar disorder (mood disorder)

30-39:

Back pain
Chest discomfort
Heart rate irregular
Pain

40-49:

Blood pressure increased
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Essential tremor
Intention tremor (brain tremor)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Presyncope

50-59:

n/a

60+:

Exfoliative rash (scaly red generalized skin rash)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pyrexia (fever)
Sputum increased
Stomatitis (inflammation of mucous membrane of mouth)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 29.63%
Immunodeficiency Common Variable: 3 people, 11.11%
Stress And Anxiety: 2 people, 7.41%
Neuralgia (pain in one or more nerves): 2 people, 7.41%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 2 people, 7.41%
Appetite Disorder (abnormal eating habits): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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