Lactulose and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lactulose (lactulose) and Naltrexone (naltrexone). Common drug interactions include drug intolerance among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Lactulose and Naltrexone. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On Jul, 20, 2026

30 people who take Lactulose and Naltrexone together, and have interactions are studied.

Lactulose and Naltrexone drug interactions.

What are the common drug interactions of Lactulose and Naltrexone, by gender? *:

female:

Drug intolerance (drug sensitivity)
Fungal infection
Impaired gastric emptying
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vocal cord disorder
Drug ineffective
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bruxism (habitual grinding of the teeth, typically during sleep)
Costochondritis (chest wall pain)

male:

Abdominal distension
Device dislocation
Chronic kidney disease
Confusional state
Death
Diarrhoea
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haematemesis (vomiting of blood)
Hyperkalaemia (damage to or disease of the kidney)
Joint swelling

What are the common drug interactions of Lactulose and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device dislocation
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight gain poor
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Lip swelling
Pyrexia (fever)
Rash erythematous (redness of the skin)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Skin exfoliation (removal of the oldest dead skin cells)

10-19:

Abdominal distension
Aggression
Intentional self-injury
Irritability
Abdominal pain

20-29:

n/a

30-39:

n/a

40-49:

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Haematemesis (vomiting of blood)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)

50-59:

Diarrhoea
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Joint swelling
Lung infection
Lymphocyte count decreased
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Peripheral swelling

60+:

Pulmonary embolism (blockage of the main artery of the lung)
Abdominal distension
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Adverse event
Chronic kidney disease
Confusional state
Death
Hyperkalaemia (damage to or disease of the kidney)
Melaena (the passage of black, tarry stools)

What are the existing conditions these people have? *

Pain: 7 people, 23.33%
Sleep Disorder: 6 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 13.33%
Respiratory Disorder (respiratory disease): 4 people, 13.33%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 4 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.33%
Abdominal Pain: 3 people, 10.00%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 3 people, 10.00%
Drowsiness: 3 people, 10.00%
Fever: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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