Lactulose and Propulsid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lactulose (lactulose) and Propulsid (cisapride monohydrate). Common drug interactions include headache among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lactulose and Propulsid. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

What is Propulsid?

Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.



On Jul, 26, 2026

95 people who take Lactulose and Propulsid together, and have interactions are studied.

Lactulose and Propulsid drug interactions.

What are the common drug interactions of Lactulose and Propulsid, by gender? *:

female:

  1. Headache (pain in head)
  2. Renal failure (kidney dysfunction)
  3. Chronic kidney disease
  4. Cardiac disorder
  5. Hypertension (high blood pressure)
  6. Hypokalaemia (low potassium)
  7. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Urinary tract infection
  10. Vomiting

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Chest pain
  3. Anaemia (lack of blood)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Depression
  6. Renal failure (kidney dysfunction)
  7. Dehydration (dryness resulting from the removal of water)
  8. Vomiting
  9. Cardiac failure congestive
  10. Emotional distress

What are the common drug interactions of Lactulose and Propulsid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Drug maladministration
  2. Apnoea (suspension of external breathing)
  3. Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
  4. Palpitations (feelings or sensations that your heart is pounding or racing)
  5. Arrhythmia (irregular heartbeat)
  6. Disturbance in attention
  7. Overdose

10-19:

  1. Apnoea (suspension of external breathing)
  2. Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
  3. Arrhythmia (irregular heartbeat)
  4. Asthma
  5. Atrioventricular block (heart block)
  6. Atrioventricular block first degree (heart block first degree)
  7. Balanitis (inflammation of the glands penis)
  8. Blood creatinine decreased
  9. Blood urea decreased
  10. Bradycardia (abnormally slow heart action)

20-29:

  1. Enteritis (inflammation of the small intestine)
  2. Flatulence (flatus expelled through the anus)
  3. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  4. Lymphadenopathy (disease or enlargement of lymph nodes)
  5. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

30-39:

  1. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  2. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  3. Abdominal pain
  4. Abdominal pain upper
  5. Dehydration (dryness resulting from the removal of water)
  6. Diarrhoea
  7. Feeling jittery
  8. Nausea (feeling of having an urge to vomit)
  9. Pruritus (severe itching of the skin)
  10. Pyrexia (fever)

40-49:

  1. Anxiety
  2. Back pain
  3. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  4. Myalgia (muscle pain)
  5. Urinary tract infection
  6. Vomiting
  7. Cardiac disorder
  8. Cardiomegaly (increased size of heart than normal)
  9. Chest pain
  10. Cough

50-59:

  1. Chronic kidney disease
  2. Chronic obstructive airways disease
  3. Conjunctivitis (pink eye)
  4. Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
  5. Dyspnoea (difficult or laboured respiration)
  6. Haemoglobin decreased
  7. Pain
  8. Renal impairment (severely reduced kidney function)
  9. Sick sinus syndrome (a collection of heart rhythm disorders)
  10. Sinus arrest (sinus pause)

60+:

  1. Cardiac failure congestive
  2. Anxiety
  3. Dehydration (dryness resulting from the removal of water)
  4. Encephalopathy (functioning of the brain is affected by some agent or condition)
  5. Fall
  6. Oxygen saturation decreased
  7. Pneumonia
  8. Pulmonary oedema (fluid accumulation in the lungs)
  9. Thrombosis (formation of a blood clot inside a blood vessel)
  10. Blood iron decreased

What are the existing conditions these people have? *

  1. Depression: 6 people, 6.32%
  2. High Blood Cholesterol: 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Lactulose and Propulsid?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lactulose and Propulsid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lactulose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Propulsid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lactulose and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Propulsid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on lactulose and cisapride monohydrate (the active ingredients of Lactulose and Propulsid, respectively), and Lactulose and Propulsid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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