Naproxen and Aygestin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Naproxen (naproxen) and Aygestin (norethindrone acetate). Common drug interactions include nausea among females.
The phase IV clinical study analyzes what interactions people have when they take Naproxen and Aygestin. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.
What is Naproxen?
Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.
What is Aygestin?
Aygestin has active ingredients of norethindrone acetate. It is often used in endometriosis. eHealthMe is studying from 1,107 Aygestin users. Check the latest studies of Aygestin.
20 people who take Naproxen and Aygestin together, and have interactions are studied.

What are the common drug interactions of Naproxen and Aygestin, by gender? *:
female:
- Nausea (feeling of having an urge to vomit)
- Arthralgia (joint pain)
- Anaemia (lack of blood)
- Arrhythmia (irregular heartbeat)
- Aspartate aminotransferase increased
- Asthma
- Bacterial infection
- Blood bilirubin increased
- Breast enlargement
- Cataplexy (loss of muscle tone accompanied by full conscious awareness)
male:
n/a
What are the common drug interactions of Naproxen and Aygestin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
30-39:
- Abdominal discomfort
- Abnormal behaviour
- Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
- Alanine aminotransferase increased
- Anaemia (lack of blood)
- Arrhythmia (irregular heartbeat)
- Arthralgia (joint pain)
- Aspartate aminotransferase increased
- Asthma
- Bacterial infection
40-49:
- Drug ineffective
- Arthralgia (joint pain)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
- Vaginal odour
- Fluid retention (an abnormal accumulation of fluid in the blood)
- Hypertension (high blood pressure)
- Joint swelling
- Metrorrhagia (uterine bleeding at irregular intervals)
- Muscular weakness (muscle weakness)
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 75.00%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 55.00%
- Drowsiness: 4 people, 20.00%
- Anaemia (lack of blood): 2 people, 10.00%
- Depression: 2 people, 10.00%
- Heavy Or Prolong Menstrual Bleeding: 2 people, 10.00%
- Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 5.00%
- Bacterial Infection: 1 person, 5.00%
- Dizziness: 1 person, 5.00%
- Dysfunctional Uterine Bleeding (Dub): 1 person, 5.00%
* Approximation only. Some reports may have incomplete information.
Do you take Naproxen and Aygestin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Naproxen and Aygestin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Naproxen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Aygestin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Naproxen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Aygestin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on naproxen and norethindrone acetate (the active ingredients of Naproxen and Aygestin, respectively), and Naproxen and Aygestin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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