Lamictal cd and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamictal cd (lamotrigine) and Depakote (divalproex sodium). Common drug interactions include rash among females and type 2 diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Lamictal cd and Depakote. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Lamictal cd?

Lamictal cd has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 1,228 Lamictal cd users. Check the latest studies of Lamictal cd.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

32 people who take Lamictal cd and Depakote together, and have interactions are studied.

Lamictal cd and Depakote drug interactions.

What are the common drug interactions of Lamictal Cd and Depakote, by gender? *:

female:

Rash
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Acne (skin problems that cause pimples)
Alanine aminotransferase increased
Ammonia increased
Anxiety
Aphthous stomatitis (mouth ulcer)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood cholesterol increased

male:

Type 2 diabetes mellitus
Vision blurred
Impaired fasting glucose
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Pneumonia
Pulmonary sarcoidosis (growth of tiny collections of inflammatory cells in lungs)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Rash

What are the common drug interactions of Lamictal Cd and Depakote, by age (0-1 to 60+)? *:

0-1:

Haematocrit decreased
Hydrocephalus (water on the brain)
Impaired healing
Joint dislocation (a joint position is changed from normal position)
Nephrolithiasis (calculi in the kidneys)
Skin discolouration (change of skin colour)
Talipes
Abdominal distension
Corneal opacity (scarring or clouding of the cornea)
Dermatitis diaper (diaper rash is a common form of inflamed skin)

2-9:

Alanine aminotransferase increased
Ammonia increased
Aspartate aminotransferase increased
Blood bilirubin increased
Central auditory processing disorder (cannot process the information they hear in the same way as others do)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)

10-19:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Aggression
Drug level decreased
Drug toxicity
Dysstasia (difficulty in standing)
Mania (a state of abnormally elevated or irritable mood)
Rash
Screaming (a long loud piercing cry)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Weight increased

20-29:

Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Blood cholesterol increased
Blood triglycerides increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diplopia (double vision)
Drug ineffective
Ill-defined disorder
Rash

30-39:

Anxiety
Aphthous stomatitis (mouth ulcer)
Depression
Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Rash
Rash erythematous (redness of the skin)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

Type 2 diabetes mellitus
Abdominal pain upper
Chest pain
Diabetes with hyperosmolarity (diabetes with increasing blood glucose levels and dehydration)
Diabetic foot
Dyslipidaemia (abnormal amount of lipids)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis c
Hypertriglyceridaemia (excess of triglycerides in the blood)
Impaired fasting glucose

50-59:

Skin ulcer
Vulvovaginal pruritus (vulvovaginal severe itching)

60+:

Confusional state
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ill-defined disorder
Insomnia (sleeplessness)
Leukopenia (less number of white blood cells in blood)
Platelet count increased
Psychotic disorder
Purpura (purplish discoloration of the skin)
Rash
Stupor (lack of critical cognitive function and level of consciousness)

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 9.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 6.25%
Depression: 2 people, 6.25%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 6.25%
Affective Disorder (mental disorder): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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