Lamisil and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamisil (terbinafine hydrochloride) and Provigil (modafinil). Common drug interactions include major depression among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Lamisil and Provigil. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Lamisil?

Lamisil has active ingredients of terbinafine hydrochloride. It is often used in pulmonary aspergilloma (mycetoma). eHealthMe is studying from 14,080 Lamisil users. Check the latest studies of Lamisil.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 30, 2026

57 people who take Lamisil and Provigil together, and have interactions are studied.

What are the common drug interactions of Lamisil and Provigil, by gender? *:

female:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mania (a state of abnormally elevated or irritable mood)
Metastatic neoplasm (spreadable cancer tumour)
Muscle spasms (muscle contraction)
Oedema mouth (swelling of mouth)
Oral discomfort (pain or irritation in mouth)
Photosensitivity reaction
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Depression
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Insomnia (sleeplessness)
Road traffic accident
Fibromyalgia (a long-term condition which causes pain all over the body)
Palpitations (feelings or sensations that your heart is pounding or racing)
Spinal disorder (disease of spine a back bone)
Therapeutic response unexpected
Confusional state
Ankle fracture

What are the common drug interactions of Lamisil and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Insomnia (sleeplessness)

30-39:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Candidiasis (candidiasis or thrush is a fungal infection)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Ankle fracture
Back injury
Cough
Dyspnoea (difficult or laboured respiration)
Rib fracture

40-49:

Renal failure acute (rapid kidney dysfunction)
Anxiety
Back pain
Blood pressure increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Euphoric mood (excessively happy but may become angry or irritable)
Feeling drunk
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Libido increased (increased sexual urge to have sex)

50-59:

Insomnia (sleeplessness)
Drug effect decreased
Fibromyalgia (a long-term condition which causes pain all over the body)
Palpitations (feelings or sensations that your heart is pounding or racing)
Road traffic accident
Spinal disorder (disease of spine a back bone)
Therapeutic response unexpected
Abdominal pain
Anxiety
Diarrhoea

60+:

Fall
Androgen deficiency
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug ineffective
Escherichia sepsis (bacterial infection by escherichia coli)
Flushing (the warm, red condition of human skin)
Foot fracture
Gastric disorder (disease of stomach)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 31.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 19.30%
Fungal Nail Infection: 5 people, 8.77%
Pain: 4 people, 7.02%
Drowsiness: 4 people, 7.02%
Stress And Anxiety: 3 people, 5.26%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 5.26%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Lamisil and Provigil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously