Lamotrigine and Coreg drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Coreg (carvedilol). Common drug interactions include anxiety among females and disturbance in attention among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Coreg. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

88 people who take Lamotrigine and Coreg together, and have interactions are studied.

Lamotrigine and Coreg drug interactions.

What are the common drug interactions of Lamotrigine and Coreg, by gender? *:

female:

Anxiety
Dizziness
Fall
Gingivitis (inflammation of gums)
Spinal osteoarthritis (joint cartilage loss in spine)
Sunburn
Weight increased
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Oral discomfort (pain or irritation in mouth)
Abdominal pain upper

male:

Disturbance in attention
Malaise (a feeling of general discomfort or uneasiness)
Cough
Gait disturbance
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the common drug interactions of Lamotrigine and Coreg, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Nerve injury
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Skin exfoliation (removal of the oldest dead skin cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Burning sensation
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Limb crushing injury (crushing injury of upper limb)
Sleep disorder due to a general medical condition
Oropharyngeal blistering (blister of oropharynx)

50-59:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rib fracture
Spinal osteoarthritis (joint cartilage loss in spine)
Vomiting
Weight increased
Injection site reaction
Nerve injury
Oropharyngeal blistering (blister of oropharynx)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Affect lability (emotional incontinence)

60+:

Diarrhoea
Pneumonia
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Blood glucose increased
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Depression: 37 people, 42.05%
High Blood Cholesterol: 13 people, 14.77%
Pain: 10 people, 11.36%
Cardiac Disorder: 10 people, 11.36%
Affective Disorder (mental disorder): 10 people, 11.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 10.23%
Mood Swings (an extreme or rapid change in mood): 8 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 7.95%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 7.95%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 7.95%

* Approximation only. Some reports may have incomplete information.

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